Abstract: Objective: To observe the curative effects of three methods in the treatment of uterine scar pregnancy(CSP). Methods: One hundred and twenty patients with CSP were randomly divided into the methotrexate(MTX) group, embolization group and combination group(40 cases each group). The MTX group, embolization group and combination group were treated with MTX intravenous injection, gelatin sponge perfusion in uterine artery and combination with the above two methods, respectively. The levels of β-human chorionic gonadotrophin(β-hCG), intraoperative and postoperative hemorrhage volume, diameter of gestational sac after 7 days of treatment, hospitalization time and clinical efficacy and adverse reactions among three groups were compared. Results: The serum levels of β-hCG in combination group after 3 days and 7 days of treatment were obviously lower than those in embolization group and MTX group(P<0.01). The total hemorrhage volume in the combination group was obviously less than that in embolization group and MTX group(P<0.01). The diameter of gestational sac after 7 days of treatment was significantly smaller than that in embolization group and MTX group(P<0.01). The time of β-hCG level recovery and hospitalization in combination group were obviously shorter than those in embolization group and MTX group(P<0.01). The differences of clinical curative effects and adverse reactions among three groups were not statistically significant(P>0.05). Conclusions: The treatment of uterine scar pregnancy with MTX perfusion combined with embolization in uterine artery has good clinical effects, and the adverse reactions do not be increased.