Abstract: Objective: To investigate the multi-slice spiral CT(MSCT) features of local infiltration in advanced colonic carcinoma. Methods: Thirty-one patients with advanced colonic carcinoma identified by histopathology were examined using the multi-slice spiral CT before operation. Compared with the histopathologic examination features, the preoperative imaging data in all cases were retrospectively analyzed. Results: Compared with the postoperative histopathological results of 31 cases with advanced colonic carcinoma, the multi-slice spiral CT imaging showed that bowel wall thickened, the intestinal fat gap had the cable or clouding high density imaging complicated with nodular and wedge-shaped shadow, which identified that the accuracy, sensitivity and specificity of local infiltration degree of tumor were 77.42, 22.58% & 80.65%, 37.50%, 13.04% &78.26%, and 91.3%, 50.00% & 87.50%, respectively, and the accuracy, sensitivity and specificity of lymph node metastses were 80.65%, 61.54% and 94.44%, respectively. Conclusions: The MSCT imaging of local infiltration in advanced colonic carcinoma show some special MSCT features, which can identify and evaluate the local infiltration degree of tumor, help to formulate the treatment protocol and predict prognosis.