Abstract: Objective: To investigate the vaccination quality of Bacillus Calmette-Guerin(BCG) in infants, analyze its related impacting factors and improve the effects of vaccination. Methods: The results of tuberculin(PPD) test in 1533 infants vaccinated with BCG and its related factors from Institute of Preventive Vaccination of Changzhou were analyzed, which was used to evaluate the quality of BCG vaccination. Results: The BCG scar rate and PPD positive rate were 94.59% and 96.09%, respectively. The differences of PPD positive rate in different gender, household register, birthweight and age were not statistically significant(P>0.05). The PPD positive rates in infants with 3 to 5 mm or more than 5 mm of BCG scar diameter were significantly higher than that in infants with less than 3 mm of BCG scar diameter(P<0.01). Conclusions: The quality of BCG vaccination is good, which meet the national immunization program criterion. The gender, household register, birthweight and age do not affect the PPD positive rate. Paying attention to the BCG quality and inoculation technique can significantly improve the inoculation effects.