汪琼, 金国玺, 于磊. 血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与2型糖尿病肾病的关系[J]. 蚌埠医科大学学报, 2016, 41(5): 586-588. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.009
    引用本文: 汪琼, 金国玺, 于磊. 血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与2型糖尿病肾病的关系[J]. 蚌埠医科大学学报, 2016, 41(5): 586-588. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.009
    WANG Qiong, JIN Guo-xi, YU Lei. The correlation of the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the type 2 diabetic nephropathy[J]. Journal of Bengbu Medical University, 2016, 41(5): 586-588. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.009
    Citation: WANG Qiong, JIN Guo-xi, YU Lei. The correlation of the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the type 2 diabetic nephropathy[J]. Journal of Bengbu Medical University, 2016, 41(5): 586-588. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.009

    血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与2型糖尿病肾病的关系

    The correlation of the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the type 2 diabetic nephropathy

    • 摘要: 目的:测定血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGF-BP3)水平,探讨其与2型糖尿病肾病的关系。方法:选择2型糖尿病患者86例,根据其尿微量白蛋白排泄率(UAER)结果分为单纯糖尿病组(SDM组)33例、早期糖尿病肾病组(EDN组)28例和临床期肾病组(CDN组)25例。检测IGF-1、IGF-BP3、UAER等指标,分析IGF-1、IGF-BP3与糖尿病肾病的发病和病情轻重的关系。结果:CDN组血清IGF-1、IGF-BP3和UAER均明显高于SDM与EDN组(P <0.01),CDN组血清IGF-1、IGF-BP3和UAER亦均明显高于EDN组(P <0.01)。 IGF-1与肌酐、尿素氮、UAER和IGF-BP3均呈正相关关系(P <0.01),与年龄和糖化血红蛋白均无相关关系(P >0.05),而与空腹血糖呈负相关关系(P <0.01)。结论:血清IGF-1、IGF-BP3水平与2型糖尿病肾病的发生发展有相关性,可作为糖尿病肾病早期的诊断指标之一。

       

      Abstract: Objective:To measure the serum levels of insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGF-BP3) in patients with type 2 diabetic nephropathy,and explore its correlation with type 2 diabetic nephropathy.Methods:According to the results of the urinary albumin excretion rate(UAER),86 patients with type 2 diabetes were divided into the simple diabetes group(SDM group,33 cases),early diabetic nephropathy group(EDN group,28 cases) and clinical stage of nephropathy group(CDN group,25 cases).The levels of the IGF-1,IGF-BP3,UAER and other indicators were detected,which was used to analyze the correlations of IGF-1 and IGF-BP3 with diabetic nephropathy.Results:The serum levels of IGF-1 and IGF-BP3 and UAER in CDN group were higher than those in SDM group and CDN group(P<0.01),the serum levels of IGF-1,IGF-BP3 and UAER in CDN group were higher than those in EDN group(P<0.01).The IGF-1 was positive correlation with the creatinine,urea nitrogen,UAER and IGF-BP3,respectively(P<0.01),the IGF-1 was correlation without age and glycosylated hemoglobin(P >0.05),and was negative correlation with fasting plasma glucose(P<0.01).Conclusions:The serum levels of IGF-1 and IGF-BP3 are related to the occurrence and development of type 2 diabetic nephropathy,which can be used as one of the early diagnosis index of diabetic nephropathy.

       

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