郭普, 乔艳, 张海涛, 陈贝, 李竞. 76株念珠菌血流感染的菌群分布及耐药分析[J]. 蚌埠医学院学报, 2016, 41(5): 661-663. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.036
    引用本文: 郭普, 乔艳, 张海涛, 陈贝, 李竞. 76株念珠菌血流感染的菌群分布及耐药分析[J]. 蚌埠医学院学报, 2016, 41(5): 661-663. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.036
    GUO Pu, QIAO Yan, ZHANG Hai-tao, CHEN Bei, LI Jing. Analysis of pathogen distribution and drug resistance in 76 cases with Candida bloodstream infection[J]. Journal of Bengbu Medical College, 2016, 41(5): 661-663. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.036
    Citation: GUO Pu, QIAO Yan, ZHANG Hai-tao, CHEN Bei, LI Jing. Analysis of pathogen distribution and drug resistance in 76 cases with Candida bloodstream infection[J]. Journal of Bengbu Medical College, 2016, 41(5): 661-663. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.036

    76株念珠菌血流感染的菌群分布及耐药分析

    Analysis of pathogen distribution and drug resistance in 76 cases with Candida bloodstream infection

    • 摘要: 目的:了解某院念珠菌血流感染的菌群分布和耐药情况,为临床合理用药提供依据。方法:对蚌埠医学院第一附属医院2010-2014年血培养结果为念珠菌的资料进行回顾性分析。结果:19 245份血培养标本中检出病原菌2 237株,其中念珠菌76株,检出率3.4%。76株念珠菌中白色念珠菌最多,占51.3%(39/76),其次为光滑念珠菌18.4%(14/76),近平滑念珠菌15.8%(12/76)。主要分布在ICU 14.5%(11/76),血液科11.8%(9/76)等。76株念珠菌对两性霉素B和5-氟胞嘧啶最为敏感,敏感率均为97.4%,伏立康唑的敏感率为96.1%,氟康唑和伊曲康唑的敏感率分别为90.8%和88.2%。结论:血培养分离的念珠菌以白色念珠菌最多,念珠菌对两性霉素B和5-氟胞嘧啶保持较高敏感性,对氟康唑、依曲康唑敏感性有所下降。

       

      Abstract: Objective:To investigate the pathogen distribution and drug resistance of Candida bloodstream infection to provide the basis for clinical rational drug use.Methods:The data of Candida infection isolated from blood culture were retrospectively analyzed in the First Affiliated Hospital of Bengbu Medical College from 2010 to 2014.Results:The 2 237 stains pathogenic bacteria were isolated from 19 245 blood culture specimens,which included 76 strains Candida,and the detection rate was 3.4%.Among the 76 strains Candida,the detect rates of Candida albicans,C.glabrata and C.parapsilosis were 51.3%(39/76),18.4%(14/76) and 15.8% (12/76),respectively,and the patients mainly came from the ICU(14.5%,11/76),and the department of Hematology(11.8%,9/76).The 76 strains Candida were the highest sensitivity to amphotericin B and flucytosine,the sensitive rate of which was 97.4%.The sensitivity rate of 76 strains Candida to voriconazole,fluconazole and itraconazole were 96.1%m,90.8% and 88.2%,respectively.Conclusions:The main pathogen of Candida isolated from bloodstream infection was Candida albicans.The sensitivities of Candida to amphotericin B and flucytosine are the highest,and the sensitive rate of Candida to fluconazole and itraconazole begin to decrease.

       

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