Abstract: Objective: To evaluate the clinical effects of nalmefene on anesthesia resuscitation in patients treated with vocal cord polypectomy.Methods: Ninety patients scheduled by vocal cord polypectomy were randomly divided into the control group(C group) and nalmefene group,and the nalmefene group were subdivided into the N1 and N2 group according to digital number table method(30 cases each group).The 0.9% of sodium chloride injection,0.25 μg/kg and 0.5 μg/kg of nalmefene were injected into the C,N1 and N2 group at end of the surgery.The changes of vital signs after 0,2 min and 10 min of administration,and after 5 min of extubation,and the breath recovery at T₂ in 3 groups were recorded.The time of eye opening,extubation and orientation recovery,and the PaO₂ and PaCO₂ after 15 min of extubation were recorded.The scores of Ramsay scale,VAS scale and postoperative adverse reaction were recorded after 5,30,60 and 120 min of extubation.Results: Compared with the C group,the incidence of breathing recovery in N1 and N2 group significantly increased after 10 min of administration,and the time of eye opening,extubation and orientation recovery significantly shortened.The PaO₂,PaCO₂ and incidence of postoperative nausea and vomiting in 3 groups significantly decreased after 15 min of extubation(P < 0.05 to P < 0.01),and the differences of whose between N1 and N2 group were not statistically significant(P > 0.05).The consciousness in N1 and N2 group after 5,30,60 and 120 min of extubation were better than that in C group(P < 0.05),and the difference of which between N1 and N2 group was not statistically significant(P > 0.05).The differences of vital signs and VAS scale at each time-point between 3 groups were not statistically significant(P > 0.05).The differences of the incidences of nausea and vomiting,and respiratory depression after extubation between three groups were statistically significant(P > 0.05).Conclusions: The treatment of vocal cord polypectomy with nalmefene has better anesthesia recovery effects and low incidence of side action,which is worthy of promotion.