Abstract: Objective: To observe the application effects of wire-reinforced epidural catheter during the anesthesia period of cesarean section.Methods: Four hundred pregnancy women treated with cesarean section under combined spinal and epidural anesthesia were randomly divided into the ordinary epidural catheter group(group A) and wire-reinforced epidural catheter group(group B) according to the digital table method(200 cases each group).The two groups were treated with combined spinal-epidural anesthesia(CSEA),and intubated the corresponding epidural catheter.Results: The incidences of the catheter difficulty,paresthesia,bleeding withdraw,prolonging catheter and bleeding after extubating in group B were lower than those in group A(P < 0.05 to P < 0.01).The incidence of the discomfort in puncture location during postoperative analgesia in group B was significantly higher than that in group A(P < 0.01).The catheter discount,straying the subarachnoid or epidural hematoma were found in two groups.Conclusions: The safety of wire-reinforced epidural catheter during the cesarean section period is better than that in ordinary epidural catheter,but which can lead to pain discomfort in catheter reserved location.