Abstract: Objective: To investigate the application value of two-dimensional ultrasound quantification indexes combined with hepatic vein waveform classification in the evaluation of liver fibrosis degree of patients with chronic hepatitis B.Methods: The hepatic morphology,essence,echo and blood flow dynamics in 106 patients with chronic hepatitis B were observed using two-dimensional ultrasound and Doppler ultrasound.The liver capsula and papernchyma,hepatic vein wall and hepatic vein spectrum waveform were recorded,which were compared with the diagnosis of liver pathology.Results: With the increasing of fibrosis degree,the comprehensive scores of liver ultrasonography increased,and the difference of which in each group was statistically significant(P < 0.01).The proportions of HV1 and HV2 type wave in phase S₀,S₁ and S₂ patients were lower than those in S₄ phase patients(P < 0.05 to P < 0.01).Conclusions: Two dimensional ultrasound quantification indexes and hepatic vein waveform classification in evaluating the liver fibrosis degree of patients with chronic hepatitis B has good guidance significance,which is worthy of promotion and use.