IL-12、IFN-γ、IL-10、IL-4和Th1/Th2在子痫前期孕妇血清中的表达水平及其意义

吕艳关; 赵玉杰; 魏红

doi:10.13898/j.cnki.issn.1000-2200.2016.06.033

IL-12、IFN-γ、IL-10、IL-4和Th1/Th2在子痫前期孕妇血清中的表达水平及其意义

The serum levels of IL-12, IFN--γ, IL-10, IL-4 and Th1/Th2 in preeclampsia patients and its significance

摘要

摘要: 目的：研究正常妊娠孕妇及子痫前期患者外周血中白细胞介素（IL）-12、γ干扰素（IFN-γ）、IL-10和IL-4的水平及临床意义，探讨辅助T细胞Th1/Th2细胞因子在子痫前期发病机制中的作用。方法：选择30例子痫前期孕妇（子痫前期组），同期住院分娩的无妊娠并发症的30例孕妇作为对照，检测2组孕妇血清中IL-12、IFN-γ、IL-10和IL-4含量并分析。结果：子痫前期组血清中的IL-12、IFN-γ蛋白水平及其mRNA含量均明显高于正常妊娠组（P < 0.01），而IL-4、IL-10及其mRNA含量均显著低于正常妊娠组（P < 0.01）。结论：Th1型细胞因子表达增加，Th2型因子减少以及Th1/Th2比例失衡可能是子痫前期发病的重要原因。

Abstract: Objective: To explore the levels IL-12,IFN-γ,IL-10 and IL-4 in peripheral blood of normal pregnant women and preeclampsia patients and its clinical significance,and investigate the role of Th1/Th2 cytokines of helper T cell in pathogenesis of preeclampsia.Methods: Thirty pregnant women with preeclampsia and 30 normal pregnant women without complications were divided into the observation group and control group,respectively.The serum levels of IL-12,IFN-γ,IL-10 and IL-4 in two groups were detected and analyzed.Results: The serum protein levels and mRNA expressions of IL-12 and IFN-γ in observation group were higher than that in control group(P < 0.01).The serum protein levels and mRNA expressions of IL-4 and IL-10 in observation group were lower than control group(P < 0.01).Conclusions: The type Th1cytokine expression increasing,the Th2 expression decreasing and proportion imbalance of Th1/Th2 may be the important causes of preeclampsia.

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