Abstract: Objective: To investigate the effects of humanistic care nursing combined with functional exercise on the anxiety and bone density of patients with osteoporosis.Methods: Ninety-eight osteoporosis patients treated with conventional treatment were randomly divided into the control group and observation group(49 cases each group).The control group were nursed with conventional method,the observation group were nursed with humanistic care nursing and functional exercise.The total efficiency of treatment,Hamilton anxiety score,Hamilton depression score,bone density and life quality between two groups were compared.Results: The total efficiency of treatment in observation group was higher than that in control group(P < 0.05).After treatment,the Hamilton anxiety score and Hamilton depression score in observation group were notably lower than those in control group(P < 0.01).The bone densities of femoral neck and lumbar L₁ to L₄,and each dimension score of life quality in observation group were significantly higher than those in control group(P < 0.01).Conclusions: The effects of humanistic care nursing combined with functional exercise on osteoporosis are good,which can significantly alleviate the anxiety and depression,increase the bone density and improve the life quality in patients with osteoporosis.