Abstract: Objective: To investigate the optimal anesthesia program and its effects during the course of high intensity focused ultrasound(HIFU)-knife in the treatment of hepatic hemangioma.Methods: Sixty patients with hepatic hemangioma were randomly divided into the control group and observation group.The control group and observation group were treated with conventional resection and HIFU-knife,respectively.The anesthesia program and clinical effects between two groups were compared and analyzed.Results: The stage ASA Ⅰ anesthesia effect in 52 cases were identified,the good rate of which was 86.7%.The operation time,recovery time and visual analogue scale scores in observation group were significantly better than those in control group(P<0.01).Conclusions: The treatment of hepatic hemangioma with HIFU-knife is effective and small trauma.The anesthesia during the operation can play positive effects on the operation,treatment and recovery of the disease.