时鹏, 屈洪党, 李强, 陈育华, 李倩倩, 谢静. 帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义[J]. 蚌埠医学院学报, 2016, 41(9): 1132-1135. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.004
    引用本文: 时鹏, 屈洪党, 李强, 陈育华, 李倩倩, 谢静. 帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义[J]. 蚌埠医学院学报, 2016, 41(9): 1132-1135. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.004
    SHI Peng, QU Hong-dang, LI Qiang, CHEN Yu-hua, LI Qian-qian, XIE Jing. The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance[J]. Journal of Bengbu Medical College, 2016, 41(9): 1132-1135. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.004
    Citation: SHI Peng, QU Hong-dang, LI Qiang, CHEN Yu-hua, LI Qian-qian, XIE Jing. The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance[J]. Journal of Bengbu Medical College, 2016, 41(9): 1132-1135. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.004

    帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义

    The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance

    • 摘要: 目的:检测帕金森病(PD)患者血清活化T细胞趋化因子(RANTES)水平及炎症因子白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α的变化,探讨其在PD免疫异常发病机制中的作用。方法:采用ELISA法检测60例PD患者(PD组)和35名健康体检者(对照组)血清RANTES、IL-1β、IL-6、TNF-α水平,采用Hoehn-Yahr、UPDRS量表分别对PD患者进行病情评估,同时对2组年龄、性别、吸烟、饮酒、血糖、血压、血脂差异一般状况进行检查。结果:PD组患者血清RANTES、IL-1β、IL-6和TNF-α水平均显著高于对照组(P<0.01);PD 1~5期患者血清RANTES水平差异均有统计学意义(P < 0.05~P < 0.01),而1~5期患者血清IL-1β、IL-6和TNF-α水平差异均无统计学意义(P>0.05);PD患者UPDR评分组间血清RANTES水平轻、中和重度组差异均有统计学意义(P<0.01),而IL-1β、IL-6和TNF-α水平轻、中和重度各组间差异均无统计学意义(P>0.05),且PD组血清RANTES水平与UPDRS评分呈显著正相关关系(P<0.01)。结论:PD患者血清RANTES、IL-1β、IL-6、TNF-α水平均较对照组有显著升高,提示炎症因子可能发动并维持了PD的发病进程,可为PD患者早期发现、防治提供优先依据。

       

      Abstract: Objective: To detect the levels of serum activated T cells chemokines(RANTES) and inflammatory cytokinesincluding interleukin(IL)-1β,IL-6 and tumor necrosis factor(TNF)-α in Parkinson's disease(PD) patients,and explore its roles in abnormal immune pathogenesis of PD.Methods: The serum levels of RANTES,IL-1β,IL-6 and TNF-α in 60 PD patients(PD group) and 35 healthy people(control group) were examined using the ELISA method.The disease of PD patients was evaluated using the UPDRS and Hoehn-Yahr score.The age,sex,smoking,drinking alcohol,blood glucose,blood pressure and blood lipid in two groups were examined.Results: The serum levels of the RANTES,IL-1β,IL-6 and TNF-α in PD group were significantly higher than those in control group(P<0.01).The differences of the serum RANTES levels in stage 1 to 5 PD patients were statistically significant(P<0.05 to P<0.01),but for the differences of the serum levels of IL-1β,IL-6 and TNF-α were not statistically significant(P>0.05).The differences of the serum RANTES levels between the mild,moderate and severe PD patients identified by the UPDRS were statistically significant(P<0.01),but for the differences of the levels of IL-1β、IL-6 and TNF-α were not statistically significant(P>0.05),and the level of RANTES was significantly positive correlation with the UPDRS score(P<0.01).Conclusions: Compared with control group,the levels of RANTES,IL-1β,IL-6 and TNF-α in PD patients increase,which suggest that the inflammatory cytokines may initiate and sustain the process of pathogenesis of PD,and provide the reference in early finding and treating the PD.

       

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