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    周媛, 杨小迪. 血尿酸和脑钠肽水平与进展性缺血性脑卒中的相关性研究[J]. 蚌埠医科大学学报, 2016, 41(9): 1152-1154. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.011
    引用本文: 周媛, 杨小迪. 血尿酸和脑钠肽水平与进展性缺血性脑卒中的相关性研究[J]. 蚌埠医科大学学报, 2016, 41(9): 1152-1154. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.011
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    ZHOU Yuan, YANG Xiao-di. The correlation study between the levels of serum uric acid and brain natriuretic peptide in patients with progressive ischemic stroke[J]. Journal of Bengbu Medical University, 2016, 41(9): 1152-1154. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.011
    Citation: ZHOU Yuan, YANG Xiao-di. The correlation study between the levels of serum uric acid and brain natriuretic peptide in patients with progressive ischemic stroke[J]. Journal of Bengbu Medical University, 2016, 41(9): 1152-1154. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.011
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    血尿酸和脑钠肽水平与进展性缺血性脑卒中的相关性研究

    The correlation study between the levels of serum uric acid and brain natriuretic peptide in patients with progressive ischemic stroke

      摘要
    • 摘要: 目的：探讨血尿酸（UA）和N端脑钠肽前体（NT-proBNP）水平与进展性缺血性脑卒中（PIS）的相关性。方法：选择脑卒中患者64例，其中PIS患者34例（PIS组），非PIS患者30例（NPIS组），测定并比较2组患者UA和NT-proBNP水平。并根据美国国立卫生院神经功能缺损评分（NIHSS）将PIS组患者分为轻型组、中型组和重型组，根据CT/MRI影像学检查，将其分为小灶组、中灶组和大灶组，分别测定并比较各组UA和NT-proBNP水平。结果：PIS组患者血清UA和NT-proBNP水平均明显高于NPIS组（P<0.01）。PIS组中，随NIHSS评分增加，轻型、中型、重型组患者的UA和NT-proBNP水平逐渐升高（P < 0.05～P < 0.01）；随梗死灶体积增大，小灶、中灶、大灶组患者UA和NT-proBNP水平逐渐升高（P<0.01）。结论：UA和NT-proBNP水平可反映IS病程发展程度和梗死范围，对PIS的及时诊断和治疗有重要临床意义。

       

      Abstract: Objective: To investigate the relationship between the levels of serum uric acid(UA) and N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with progressive ischemic stroke(PIS).Methods: The serum levels of UA and NT-proBNP in PIS patients(34 cases,PIS group) and Non-PIS patients(30 cases,NPIS group) were determined.The PIS group were subdivided into the light group,medium group and heavy group according to the score of National Institute of Health Stroke Scale(NIHSS).The PIS group were subdivided into the small lesion group,medium lesion group and large lesion group according to the results of the CT/MRI examination.The levels of UA and NT-proBNP between all groups were compared.Results: The levels of UA and NT-proBNP in PSI group were significantly higher than those in NPSI group(P<0.01).With the increasing of the score of NIHSS in PIS group,the levels of UA and NT-proBNP gradually increased in light,medium and heavy patients(P<0.05 to P<0.01),and with the increasing of the volume of lesion in PIS group,the levels of UA and NT-proBNP gradually increased in small,medium and large lesion patients(P<0.01).Conclusions: The levels of UA and NT-proBNP can reflect the progress and infarct size of ischemic stroke,which has important significance in the diagnosis and treatment of PIS.

       

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