Abstract: Objective: To explore the influencing factors of parathyroid function impairment after thyroid cancer radical.Methods: The clinical data of 92 cases patients with thyroid cancer radical from September 2010 to October 2015 in hospital surgical were collected,they were divided into decline group and no decline group according to whether the postoperative parathyroid function,the age,sex,clinical staging,operation mode,whether parathyroid autograft,whether sponsored by the lymph node in VIarea were compared between two groups,the influencing factors of parathyroid function impairment after thyroid cancer radical was analyzed by multiariable Logistic regression analysis.Results: There were 28 cases patients with parathyroid function impairment among 92 cases patients with thyroid cancer radical,the incidence was 30.43%.Single factor analysis showed that the differences of age,sex,clinical stage had no statistical significance between two groups(P>0.05);Cognitive impairment operation method for thyroid full cut,parathyroid autograft and sponsored by the lymph node area ratio were higher than patients with cognitive impairment(P<0.05 to P<0.01).Unconditioned multiariable logistic regression analysis showed that the operation way,behold,the lymph node zone were risk factors of parathyroid function impairment after thyroid cancer radical(OR values were respectively 3.317,2.183).Conclusions: The risk of parathyroid function impairment after thyroid cancer radical increased significantly in those patients with lymph node cleaning at VI area and thyroid full cut.