Abstract:
Objective: To investigate the hepatic perfusion index(HPI) and vascular permeability parameters in patients with different hepatic tumors,which included hepatocellular carcinoma(HCC),hepatic metastasis(HM) and hepatic haemangiomas(HH),and discuss the clinical diagnosis value of DCE-MRI.
Methods: Fifty-eight patients with hepatic tumors(30 cases of HCC,16 cases of HM and 12 cases HH) were detected by the 3D whole-liver dynamic contrast enhance MRI(DCE-MRI) using volumetric interpolated body examination(VIBE) sequence.The perfusion and vascular permeability parameters(including HPI,
Ktrans,
kep,
ve and
vp) were measured by the Omni-Kinetics software combined with liver model of dual input hemodynamics.
Results: There was statistical difference in the values of HPI,
Ktrans and
kep between three groups(
P<0.05 to
P<0.01).The HPI value in HCC group was significantly higher than that in HH group,and the HPI value was the lowest in HM group(
P<0.05).The
Ktrans value in HH group was significantly lower than that in HCC group,and the value was the lowest in HM group(
P<0.05 to
P<0.01).The
kep value in HCC group was higher than that in HH and HM groups(
P<0.01),but there was no statistical difference between HH and HM groups(
P>0.05).The differences of the
vp and
ve values between three groups were not statistically significant(
P>0.05).
Conclusions: Three-dimensional whole-liver DCE-MRI with the bolus injection of gadodiamide can be used to quantify the perfusion and permeability parameters of hepatic tumors,which is benefit to the differentiation diagnosis of hepatic tumors.