Abstract: Objective: To explore the value of quantitative detection of diffusion weighted imaging(DWI) and dynamic contrast-enhanced MRI(DCE-MRI) in the differentiation diagnosis of malignant and benign lesions of prostate.Methods: The quantitative parameters of DWI and DCE-MRI in 15 cases with prostate cancer were retrospectively analyzed.The quantitative parameters included the ADC,K^trans,k_ep and v_e,and which was statistically analyzed by SPSS.Results: The values of the ADC,K^trans and k_ep in malignant lesion and benign lesion of prostate were (1.21±0.26) mm²/s and (0.83±0.32)mm²/s,(0.45±0.22)min^-1 and (0.17±0.08)min^-1,and(0.95±0.44) min^-1 and (0.49±0.26)min^-1,respectively,the difference of which was statistically significant(P<0.01).Conclusions: The values of the ADC,K^trans and k_ep between malignant lesion and benign lesion of prostate are different,and the quantitative assessment of DWI and DCE-MRI has certain value in the differentiation diagnosis of malignant lesion and benign lesion of prostate.