铜绿假单胞菌L型对第三代和第四代头孢菌素的药物敏感性研究

Study on drug sensitivity of Pseudomonas aeruginosa L-forms to the third and forth generation cephalosporins

摘要: 目的：探讨铜绿假单胞菌（Pseudomonas aeruginosa，PA）L型对第三代和第四代头孢菌素敏感及耐药状况。方法：将PA诱导成稳定的L型，利用K-B纸片琼脂扩散法检测PA原菌及其L型对第三代和第四代头孢菌素的敏感程度，分析PA-L型的耐药状况。结果：PA-L型对第三代和第四代头孢菌素的抑菌圈直径均较原菌缩小（P<0.05），但仍维持在敏感程度。结论：PA-L型对第三代和第四代头孢菌素仍具有敏感性。

Abstract: Objective: To study the drug sensitivity of L-forms of Pseudomonas aeruginosa(PA) to the third and forth generation cephalosporins.Methods: PA was induced into a stable L-form.The drug sensitivity of PA L-forms to the third and forth generation cephalosporins was analyzed by K-B drug sensitivity test.The change trend of drug sensitivity and resistance of PA L-forms was analyzed.Results: The inhibition zone of PA L-forms was smaller than that of their parent bacteria,and there had the significant difference(P<0.05).But the drug sensitivity of L-forms of PA to the third and forth generation cephalosporins was still sensitive.Conclusions: The drug sensitivity of PA L-forms to the third and forth generation cephalosporins is still sensitive.