Abstract: Objective:To evaluate the blood perfusion change of cerebral after carotid artery stenting using CT perfusion imaging(CTP).Methods:Twenty-three patients with carotid stenosis were divided into the symptomatic group(n=13) and asymptomatic group(n=10).The medium or severe unilateral internal carotid artery stenosis patients were diagnosed using the cerebral digital subtraction angiography/CT angiography.All patients were treated with the carotid artery stenting,two groups was not,statistically significaat(P>0.05) and examined using brain CTP before operation and after 7 days of operation.The relative regional cerebral blood flow(rCBF),relative regional cerebral blood volume(rCBV),relative regional mean transit time(rMTT) and relative regional time to peak(rTTP) between two groups were compared after 7 days of operation.Results:The postoperative time of rTTP and rMTT shortened,but the diffence between the two groups was not statistically significant(P>0.05),the postoperative time of rCBF,rCBV was statistically significant(P<0.05 to P<0.01).Compared with the healthy side,the time of rTTP and rCBV prolonged,and the time of rCBF increased in affected side(P<0.01).The difference of the time of rCBV between the healthy side and affected side was not statistically significant(P>0.05).The CTP imaging after 7 days of operation showed the differences of the time of rCBF and rCBV between the healthy side and affected side were not statistically significant(P>0.05).The rTTP and rMTT in affected side were improved after operation(P<0.05 and P<0.01),and which obviously delayed compared with the healthy side(P<0.05).Conclusions:The CTP maybe accurately reflect the cerebral hemodynamic status in patients with carotid artery stenosis before and after stenting,which can be used as a noninvasive evaluating method for cerebral hemodynamic change after carotid artery stenting.The rTTP is a very sensitive index for evaluating early ischemia and compensator capacity of collateral circulation.