Abstract: Objective:To investigate the effects of the situation simulation teaching of emergency nursing skills for further improving the comprehensive competence of first-aid knowledge and skills of students.Methods:Using the cluster sampling,138 students from nurse department grade 2013 and 142 students from dental and obstetric department grade 2013 were divided into the observation group and control group,respectively.The observation group and control group were trained using the traditional demonstration and situation simulation,respectively.After finishing practice,the comprehensive effect of situation simulation teaching was investigated using questionnaire,and the course achievement was analyzed.Results:The scores of the single manipulation skill,first-aid comprehensive skill and theory in observation group were higher than those in control group(P<0.01).The evaluation of student on the situation simulation teaching was better.Among 12 items,no student selected the "no-help" and "uncertainty" items,and 93.5% to 100% students selected "great help" item.Some factors influencing situation simulation teaching were found by qualitative interview and student reflection.Conclusions:The situation simulation practice can help to improve the emergency nursing abilities of students.