CYP4F2基因多态性与云南汉族人群冠心病的相关性研究

王晓焕; 张云坤; 傅薇; 曹鸿鹍

doi:10.13898/j.cnki.issn.1000-2200.2017.05.002

CYP4F2基因多态性与云南汉族人群冠心病的相关性研究

Study of the correlation between the gene polymorphism of CYP24F2 and coronary heart disease in Yunnan Han population

摘要

摘要: 目的：研究CYP4F2基因多态性与中国云南汉族人群冠心病（CHD）的相关性。方法：采用Sequenom MassARRAY^®对云南汉族人群198名正常人（对照组）和514例CHD病人（CHD组）CYP4F2基因rs2108622、rs3093135两个单核苷酸多肽位点的多态性进行基因分型，分析该基因多态性与CHD的相关性。结果：对照组和CHD组两个等位基因频率分布差异有统计学意义（P<0.01）；校正年龄、性别、体质量指数等因素后logistic回归分析显示rs2108622位点携带T等位基因者患CHD的风险降低（P<0.05）；rs3093135位点携带A等位基因者患CHD风险降低（P<0.05）。结论：CYP4F2基因多态性与云南汉族人群CHD发生风险相关。

Abstract: Objective: To investigate the correlation between the gene polymorphism of CYP4F2 and coronary heart disease(CHD) in Yunnan Han population.Methods: The polymorphisms of rs2108622 and rs3093135 single nucleotide polymorphism(SNP) in CYP4F2 gene of 198 normal people(control group) and 514 patients with CHD(CHD group) were genotyped using the SEQUENOM Mass-ARRAY system.The correlation between the gene polymorphism of CYP4F2 and CHD was analyzed.Results: The difference of two allele frequencies between two group was statistically significant(P<0.01).After adjusting the age,gender and body mass index,the logistic regression analysis showed that the CHD risk of patients with rs2108622 T allele decreased(P<0.05),and the CHD risk of patients with rs3093135 A allele decreased(P<0.05).Conclusions: The gene polymorphism of CYP4F2 is correlated with the risk of the CHD in Yunnan Han population.

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