不同剂量乙醇对垂体后叶素致家兔急性心肌缺血的影响

闵凤; 胡志远; 牛放; 姚瑞雪; 韩雅玲; 于影

doi:10.13898/j.cnki.issn.1000-2200.2017.05.003

不同剂量乙醇对垂体后叶素致家兔急性心肌缺血的影响

Effect of different doses of ethanol on the acute myocardial ischemia induced by pituitrin in rabbits

摘要

摘要: 目的：探讨不同剂量乙醇对急性心肌缺血的影响。方法：36只家兔随机分为6组：对照组、垂体后叶素组、5%乙醇+垂体后叶素组、10%乙醇+垂体后叶素组、20%乙醇+垂体后叶素组、30%乙醇+垂体后叶素组。观察不同给药组血流动力学、心电图指标，实验结束后测定血浆肌酸激酶（CK）、乳酸脱氢酶（LDH）活性。结果：与对照组比较，垂体后叶素组和30%乙醇+垂体后叶素组心电图ST段抬高、T波在1 min、3 min和5 min时幅度均增高，血浆CK、LDH活性均增加（P<0.05）；与垂体后叶素组比较，5%乙醇+垂体后叶素组和10%乙醇+垂体后叶素组ST段、T波幅度均下降，血浆CK和LDH活性均降低（P<0.05）。结论：5%乙醇和10%乙醇对垂体后叶素所致家兔急性心肌缺血有保护作用，而30%乙醇加重垂体后叶素诱导的心肌缺血。

Abstract: Objective: To investigate the effects of different doses of ethanol on acute myocardial ischemia in rabbits.Methods: Thirty six rabbits were randomly divided into the control group, pituitrin group,5% ethanol+pituitrin group,10% ethanol+pituitrin group,20% ethanol+pituitrin group and 30% ethanol+pituitrin group.The hemodynamics and electrocardiogram in different groups were observed. After the end of the experiment,the activities of plasma creatine kinase(CK)and lactate dehydrogenase(LDH)were measured.Results: Compared with the cotrol group,the ST segment significantly elevated,the breadth of T wave at 1 min,3 min and 5 min significantly increased,and the activities of CK and LDH significantly increased in pituitrin group and 30% ethanol+ pituitrin group(P<0.05).Compared with pituitrin group,the ST segment and T wave breadth decreased,and the activities of CK and LDH significantly increased in 5% ethanol+ pituitrin group and 10% ethanol+pituitrin group(P<0.05). Conclusions: The 5% and 10% ethanol have protective effects on acute myocardial ischemia induced by pituitrin in rabbits, while 30% ethanol can aggravate the myocardial ischemia.

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