Abstract: Objective: To investigate the dynamic expressions of P-glycoprotein(PGP) and multidrug resistance protein 1(MRP1) in amygdala-kindled epileptic model of rat.Methods: Forty adult male rats were randomly divided into the model group and control group(20 rats each group).The amygdala-kindled seizure model was established in model group,and the electrode was implanted into the control group without stimulation.The brain tissue samples in two groups were harvested,and detected using immunohistochemistry method.At 24 h,7 d and 30 d of establishing model,the numbers of PGP and MRP1-positive cells in cortex and hippocampus of two groups were calculated,and the mRNA expressions of PGP and MRP1 mRNA in cortex and hippocampus of two groups were detected using RT-PCR.Results: After 24 h,7 d and 30 d of establishing model,the positive cells and mRNA expressions of PGP and MRP1 in cortex and hippocampus in model group were higher than those in control group(P<0.05 to P<0.01).The positive cells and mRNA expressions of PGP and MRP1 in cortex and hippocampus after 30 d of establishing model were higher than those at 24 h of establishing model in model group(P<0.05),but the difference of which at different time-points in control group was not statistically significant(P>0.05).Conclusions: The expession of PGP and MRP1 increases in cortex and hippocampus of amygdala-kindled epileptic rat,with the lengthening of time,it gradually increases in amygdala-kindled epileptic model.