Abstract: Objective: To investigate the risk factor of agitation in general surgical inpatients after general anesthesia.Methods: The effects of the preoperative and intraoperative variables on the incidence of agitation during awakening in 514 general surgical inpatients were retrospectively analyzed after general anesthesia.The risk factors were screened using single factor and multiple factor regression equation analysis.Results: Among 514 patients,the severe agitation in 32 cases was found.Single factor analysis showed that the proportions of gender,ASA grade,intraoperative fluid infusion,postoperative anemia,indwelling catheter and VAS more than 4 points in agitation patients were significantly higher than those in quiet patients(P<0.05 to P<0.01).Multivariate analysis showed that the ASA classification,indwelling catheter,intraoperative fluid infusion and postoperative VAS more than 4 points were the risk factors of agitation after general anesthesia.Conclusions: Patients with high ASA grade,indwelling catheter,large amount of fluid infusion and severe surgical pain should be treated with positive postoperative stabilization to prevent agitation.