Abstract: Objective: To investigate the clinical efficacy and safety of edaravone combined with ozagrel in the treatment of ischemic stroke(IS).Methods: Eighty patients with acute ischemic stroke were randomly devided into the control group and observation group according to the random number methods.The control group and observation group were treated with ozagrel and edaravone combined with ozagrel,respectively.The score of modified Edinburgh Scandinavia Scandinavian scale(MESSS),index score of activity of daily living scale(ADL),clinical efficacy and adverse reaction between two groups were compared 7 d,14 d and 30 d after treatment.Results: Compared with the control group,the MESSS score and ADL index score in observation group significantly decreased and increased 7 d,14 d and 30 d after treatment,respectively(P<0.01).The clinical efficacy in observation group was better than that in control group(P<0.05).No obvious adverse reaction in the two groups was found during the treatment.Conclusions: The treatment of edaravone combined with ozagrel can significantly improve the neural function and daily living ability,which is good clinical efficacy,less adverse reaction,and worthy of clinical promotion.