许娟娟, 许力, 李云云, 屈洪党. 视神经脊髓炎谱系病病人血清AQP4-IgG水平及其临床意义[J]. 蚌埠医学院学报, 2017, 42(7): 861-863. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.007
    引用本文: 许娟娟, 许力, 李云云, 屈洪党. 视神经脊髓炎谱系病病人血清AQP4-IgG水平及其临床意义[J]. 蚌埠医学院学报, 2017, 42(7): 861-863. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.007
    XU Juan-juan, XU Li, LI Yun-yun, QU Hong-dang. Serum levels of AQP4-IgG in patients with neuromyelitis optica spectrum disorders and its clinical significance[J]. Journal of Bengbu Medical College, 2017, 42(7): 861-863. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.007
    Citation: XU Juan-juan, XU Li, LI Yun-yun, QU Hong-dang. Serum levels of AQP4-IgG in patients with neuromyelitis optica spectrum disorders and its clinical significance[J]. Journal of Bengbu Medical College, 2017, 42(7): 861-863. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.007

    视神经脊髓炎谱系病病人血清AQP4-IgG水平及其临床意义

    Serum levels of AQP4-IgG in patients with neuromyelitis optica spectrum disorders and its clinical significance

    • 摘要: 目的:探讨视神经脊髓炎谱系病(NMOSD)病人血清水通道蛋白4-抗体(AQP4-IgG)水平与临床特征的相关性。方法:选取确诊的NMOSD病人38例,记录扩展残疾状态量表(EDSS)评分,采用间接免疫荧光法检测血清AQP4-IgG水平,分析其水平与临床症状、影像学表现的相关性。结果:AQP4-IgG抗体阳性组23例(60.5%),阴性组15例(39.5%),阳性组EDSS评分显著高于阴性组(P<0.05);Spearman相关性分析发现,血清AQP-4 IgG与 EDSS 评分、脊髓受累节段数均呈正相关关系(P<0.01)。抗体阳性组3例复发,阴性组无复发病例。结论:NMOSD AQP4-IgG抗体阳性病人神经功能缺损症状重,且抗体水平越高,脊髓受累节段多,预后较差,较AQP4-IgG抗体阴性病人易复发。

       

      Abstract: Objective:To investigate the correlation between the serum level of aquaporin 4-antibody(AQP4-IgG) and the clinical feature in patients with neuromyelitis optica spectrum disorders(NMOSD).Methods:The score of the expanded disability status scale(EDSS) and serum levels of AQP4-IgG detected by indirect immunofluorescence assay in 38 NMOSD cases were investigated.The correlations between serum level of AQP4-IgG,clinical symptom,image manifestation were analyzed.Results:The positive AQP4-IgG antibody in 23 cases(60.5%) and AQP4-IgG negative antibody in 15 cases(39.5%) were identified,and the EDSS score in positive group was significantly higher than that in negative group(P<0.05).Spearman correlation analysis showed that the serum level of AQP4-IgG antibody was positive correlation with the EDSS score and lesion segment of spinal cord(P<0.01).Three cases recurred in positive group,and no case recurred in negative group.Conclusions:The nerve impairment in NMOSD patients with AQP4-IgG antibody positive is severe.The higher the antibody and more spinal cord lesion are,the poorer the prognosis is.The patient with AQP4-IgG antibody negative is easy to recur.

       

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