Abstract: Objective:To explore the value of the plasma levels of BNP,CRP and D-dimer in evaluating the aged patients with atrial fibrillation(AF) complicated with chronic heart failure(CHF).Methods:The clinical data of 46 aged patients with AF complicated with CHF(AF group) and 46 aged patients with CHF complicated with sinus rhythm(sinus rhythm group)from December 2014 to December 2016 were retrospective analyzed.The patients were divided into gradeⅡ,Ⅲ and Ⅳ groups according to the NYHA heart function classification.The differences and correlations of BNP,CRP,D-dimer and LVEF between two groups were compared.Results:At the same heart function classification,the levels of plasma BNP,CRP and D-dimer in AF group were significantly higher than those in sinus rhythm group(P<0.01),and the levels of plasma BNP,CRP and D-dimer in two groups increased with the increasing of heart function classification(P<0.01).The LVEF in AF group was significantly lower than that in sinus rhythm group(P< 0.01).The levels of BNP and CRP were positively correlated with the cardiac function classification in aged patients with CHF complicated with AF.Conclusions:The levels of BNP,CRP and D-dimer in aged patients with CHF complicated with AF increase,which is significantly higher than those in sinus rhythm patients,and correlated with the severity of the disease.The combined detection has important significances in diagnosing the disease severity and prognosis of patients.