Abstract:
Objective:To investigate the significance of the serum cystatin C(CysC),microdose albumin(mAlb) and β
2-microglobulin(β
2-MG) detection in the diagnosis and prognosis of the acute kidney injury(AKI).
Methods:Ninety-seven AKI patients were divided into the stage AKI 1(45 cases),stage AKI 2(27 cases) and stage AKI 3(25 cases),and 55 healthy people were set as the control group.The levels of CysC,mAlb and β
2-MG were detected in each group,and the scores of acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) in all cases were evaluated.
Results:The differences of the serum levels of CysC,mAlb and urine β
2-MG between fours groups were statistically significant(
P<0.01),the levels of CysC,mAlb and urine β
2-MG in AKI groups were significantly higher than those in control group(
P<0.01),the levels of CysC,mAlb and urine β
2-MG in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(
P<0.01),and the levels of CysC,mAlb and urine β
2-MG in AKI 3 groups were significantly higher than those in AKI 2 group(
P<0.01).The differences of the scores of APACHEⅡ between four groups were statistically significant(
P<0.01),the scores of APACHEⅡ in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(
P<0.01),and the score of APACHEⅡ in AKI 3 group was significantly higher than that in AKI 2 group(
P<0.01).The levels of serum CysC,mAlb and urine β
2-MG were significantly positive correlated with APACHEⅡ score(
P<0.01).The positive rate of the combined detection of serum CysC,mAlb and β
2-MG in the diagnosis of AKI was significantly higher than that of the independent 3 indicator(
P<0.05).The levels of serum CysC,mAlb,urine β
2-MG and APACHEⅡ score in survival cases were significantly lower than those in death cases(
P<0.01).
Conclusions:The serum CysC,mAlb and urine β
2-MG are closely related to the severity and prognosis of AKI patients,which can be used as an important indicator in evaluating the severity and prognosis of AKI patients.