Abstract: Objective: To compare the clinical characteristics and pathological features of gastric cancer(GC)in different locations.Methods: The clinical data of 62 GC patients treated with operation were retrospectively analyzed.Twenty-six cases in upper stomach(group U),16 cases in middle stomach(group M) and 20 cases in lower stomach(group L) were identified.The gender,age,alarm symptoms,pathological type,differentiation degree,Borrmann type,early diagnosis rate,rate of lymph node metastasis and distant metastasis rate between three group were compared.Results: The differences of the distributions of sex and age in different locations GC were statistically significant(P<0.05 to P<0.01).The early warning symptoms of acataposis,high differentiation degree and distant metastasis rate in group U were significanthy higher those in group M and group L(P<0.01).Conclusions: The clinical characteristics and pathological features in different locations gastric cancer are different,especially for in the upper stomach cancer,its clinical and pathological features are more prominent.