Abstract: Objective: To explore the anesthetic plan and management of epilepsy patients under the monitoring of electrocorticography(ECoG).Methods: Forty epilepsy patients treated with surgery were randomly divided into the intravenous inhalation compound anesthesia group(group A) and total intravenous anesthesia group(group B).The group A and group B were treated with sevoflurane inhalation anesthesia and intravenous infusion of propofol target-controlled,respectively.When the concentration of sevoflurane or propofol were 1.5 MAC or 5.0 μg/mL(T₁),1.0 MAC or 3.0 μg/mL(T₂) and 0.5 MAC or 1.5 μg/mL(T₃),the number of eruptive suppression wave,spike frequency and hemodynamic changes during operation were observed in the ECoG.Results: At T₂ and T₃ in two groups during operation,the ECoG could accurately record the epilepsy wave,and the hemodynamic index was stable.At T₁,the number of eruptive suppression wave in ECoG were the most.At different time-points,the differences of the hemodynamic index,number of eruptive suppression wave and spike frequency between two groups were not statistically significant(P>0.05).Conclusions: The effects of the sevoflurane and propofol on ECoG are dose-dependent in epilepsy patients,but it does not affect the epilepsy wave identification and lesion location of ECoG under a certain depth of anesthesia,and can be safely used the anesthesia of epilepsy surgery.