Abstract: Objective: To explore the effects of the collaborative care management mode on general anesthesia emergence agitation and nursing quality in patients treated with radical mastectomy.Methods: One hundred and twenty patients treated with radical mastectomy were divided into the control group(admission time from June 2014 to May 2015,n=60) and observation group(admission time from June 2015 to May 2016,n=60).The control group were nursed with routine care,and the observation group were nursed with the collaborative care management during anesthesia.The awakening time,extubation time,operation time,agitation score,postoperative pain score,incidence of agitation,sedative usage and quality of care score between two groups were compared.Results: The awakening time,extubation time and operation time in observation group were significantly shorter than those in control group(P<0.01),and the agitation score,postoperative pain score,incidence of agitation and sedative usage were lower than those in control group(P<0.05 to P<0.01).The scores of quality of nursing(including the ward management,primary care,specialist care of anesthesia,anesthesia medication management,anesthesia recovery period nursing and medical record)were significantly higher than that in control group(P<0.01).Conclusions: Collaborative care management mode can effectively achieve the rational allocation of human resources in general surgery,and closely promote the cooperation and exchange between anesthesiology department and nursing unit,which can effectively improve the postoperative nursing quality of patients treated with radical mastectomy,reduce the incidence of agitation of patients during anesthesia recovery period,and is conducive to smoothly live through the anesthesia recovery period in general anesthesia patients.