Abstract: Objective:To explore the serum levels of differentiated embryonic chondrocyte expression gene 1(DEC1) and liver X receptor β(LXRβ) in Parkinson's disease(PD),and its correlation.Methods:Fifty PD patients and 50 healthy people were divided into the PD group and control group,respectively.The serum levels of DEC1 and LXRβ in two groups were tested.Results:The serum levels of DEC1 and LXRβ in PD group were significantly higher and lower than that in control group,respectively(P<0.01).The differences of serum levels of DEC1 and LXRβ between different genders of PD group were not statistically significant(P>0.05).The serum level of LXRβ in more than or equal to 60 years old PD patients was lower than that in less than 60 years old PD patients(P<0.05).The serum levels of DEC1 and LXRβ in PD patients with cognitive dysfunction were significantly higher and lower than those in PD patients without cognitive dysfunction,respectively(P<0.01).With the deterioration of PD patients,the serum levels of DEC1 and LXRβ gradually increased and decreased,respectively(P<0.05 to P<0.01).The serum level of DEC1 was negatively correlated with the level of LXRβ in PD patients(r=-0.326,P<0.05).Conclusions:The serum level of DEC1 is negatively correlated with the level of LXRβ in PD patients,which may be involved in the onset and progression of PD.