Abstract: Objective:To analyze the influencing factors of nure's quality of life(QOL) from 4 hospitals of Lu'an city,and provide a scientific basis for improving QOL of nurses.Methods:Five hundred and twenty nurses from 4 hospitals of Lu'an from July 2016 to October 2016 were investigated using cluster random sampling method.The effective questionnaires were 472,and the effective rate of which was 90.8%.Results:The differences of the scores of physical,mental,social,enviromental fields of QOL and the overall feeling score in different ages nurses were not statistically significant(P>0.05).The scores of the social fields of QOL in married nurses were higher than those in unmarried nurses(P<0.05),while there was no statistical significance in other fields(P>0.05).The scores of mental,social and enviromental fields of QOL in nurses with monthly salary more than 4 000 yuan were more high(P<0.05).The scores of mental,social and enviromental fields in specialized chief nurse with different position were more high(P<0.05).The score of mental and social fields of QOL in nurses with night shift for 1 to 4 times a month was higher than that in nurses without night shift,and with night shift more than 4 times a month(P<0.05).Conclusions:The related department of hospital should pay more attention to the nurses with low salary,low working position and more than four times of night shift a month,and take effective measures to improve the QOL of nurses.