Abstract: Objective:To explore the carotid plaque integral,analyze the correlation between carotid plaque vulnerability and biochemical indicator in patients with progressive stroke for increasing the clinical knowledge of comprehensive intervention in carotid plaque.Methods:The integral and vulnerability of carotid plaques in 102 patients with progressive stroke were evaluated,and the correlations between carotid plaque vulnerability and biochemical indicators(fasting plasma glucose,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,lipoprotein a,homocysteine,C reactive protein and fibrinogen) were analyzed.Results:Three hundred and one plaques in 102 patients with progressive stroke were detected,which included 257 vulnerable plaques(85.4%,257/301),and the mean integral of carotid plaques was(11.24±4.56)mm.There were positive correlations between the mean integral of carotid plaques,and fasting plasma glucose,low density lipoprotein,lipoprotein a,homocysteine,C reactive protein and fibrinogen(P<0.01),and there was negative relation between the mean integral of carotid plaques and high density lipoprotein(P<0.05).The lipoprotein a,homocysteine and C reactive protein were the independent risk factors of vulnerable plaques(P<0.05).Conclusions:The carotid plaques nature is closely related to biochemical indicator in patients with progressive stroke,and the lipoprotein a,homocysteine and C reactive protein are the independent risk factors of vulnerable plaques.