Abstract: Objective:To investigate the effects of self-management intervention based on self-efficacy theory in patient with chronic obstructive pulmonary disease(COPD),and provide the evidence in optimizing medical service.Methods:One hundred and twenty-eight patients with stabilization period COPD were randomly divided into the observation group and control group(64 cases each group).The control group were nursed with routine method,and the observation group was nursed with self-management intervention based on self-efficacy theory.The heart and lung function in two groups were evaluated using the 6 min walk distance(6MWD) and medical research council scale(MRC),and the health knowledge,self-efficacy and quality of life improvement in two groups were evaluated using health knowledge questionnaire,self-efficacy scale and St.George's respiratory questionnaire(SGRQ) before and after 8 weeks of intervention.Results:Before intervention,the differences of the scores of 6MWD,MRC,health knowledge questionnaire,self-efficacy scale and SGRQ between two groups were not statistically significant(P>0.05).After intervention,the scores of 6MWD,health knowledge,self-efficacy and total score in two groups increased,and the scores of MRC and SGRQ decreased.The increasing degrees of the 6MWD,health knowledge,self-efficacy and total score in observation group were significantly more than those in control group(P<0.01),and the decreasing degrees of the MRC and SGRQ in observation group were significantly more than those in control group(P<0.01).Conclusions:Self-management intervention based on self-efficacy theory can effectively promote the recovery of patient with COPD,increase the awareness of the disease,improve self-management skill and quality of life,which is worthy of promotion.