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    马熠, 方开云. 七氟烷吸入麻醉对肝硬化行肝部分切除术病人镇痛效果及肝功能水平的影响[J]. 蚌埠医科大学学报, 2018, 43(1): 65-68. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.019
    引用本文: 马熠, 方开云. 七氟烷吸入麻醉对肝硬化行肝部分切除术病人镇痛效果及肝功能水平的影响[J]. 蚌埠医科大学学报, 2018, 43(1): 65-68. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.019
    shu
    MA Yi, FANG Kai-yun. Influence of sevoflurane anesthesia on the analgesic effect and liver function in cirrhosis patients treated with partial hepatectomy[J]. Journal of Bengbu Medical University, 2018, 43(1): 65-68. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.019
    Citation: MA Yi, FANG Kai-yun. Influence of sevoflurane anesthesia on the analgesic effect and liver function in cirrhosis patients treated with partial hepatectomy[J]. Journal of Bengbu Medical University, 2018, 43(1): 65-68. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.019
    shu

    七氟烷吸入麻醉对肝硬化行肝部分切除术病人镇痛效果及肝功能水平的影响

    Influence of sevoflurane anesthesia on the analgesic effect and liver function in cirrhosis patients treated with partial hepatectomy

      摘要
    • 摘要: 目的：探讨七氟烷吸入麻醉对肝硬化行肝部分切除术病人镇痛效果及血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）水平的影响。方法：选取肝硬化病人80例，依据随机数字表法分为七氟烷吸入麻醉组（七氟烷组，n=40）和丙泊酚泵注麻醉组（丙泊酚组，n=40），对2组病人的血清ALT、AST水平及镇痛效果进行统计分析。结果：七氟烷组病人的自主呼吸恢复时间、呼之睁眼时间及拔管时间均明显短于丙泊酚组（P<0.01），术中麻醉药每小时耗量、术中维持费用、麻醉药物费用均明显低于丙泊酚组（P<0.01）；术后2组病人的血清ALT、AST水平均明显升高（P<0.01），但2组间差异均无统计学意义（P>0.05），疼痛视觉模拟评分明显降低（P<0.01）；七氟烷组疼痛视觉模拟评分低于丙泊酚组（P<0.01）。结论：七氟烷吸入麻醉不会在极大程度上提升肝硬化病人行肝部分切除术病人血清ALT、AST水平，不会造成显著肝损害，节省费用，同时镇痛效果良好。

       

      Abstract: Objective:To investigate the influences of analgesic effect and sevoflurane anesthesia on the serum levels of ALT and AST,in cirrhosis patients treated with partial hepatectomy.Methods:Eighty cirrhotic patients were randomly divided into the sevoflurane anesthesia group(sevoflurane group,n=40) and propofol infusion anesthesia group(propofol group,n=40) according to the random number table.The serum levels of ALT and AST,and analgesic effects in two groups were statistically analyzed.Results:The spontaneous breathing recovery time,opening eye time and extubation time in sevoflurane group were significantly shorter than those in propofol group(P<0.01).The intranperative consumption amount of anesthetic drug per hour,maintaining cost and anesthetic drug cost in sevoflurane group were significantly lower than those in propofol group(P<0.01).The serum levels of ALT and AST in two groups significantly increased after operation(P<0.01),the differences of the serum levels of ALT and AST between two groups were not statistically significant after operation(P>0.05),and the VAS score in two groups significantly decreased after operation(P<0.01),and the VAS score in sevoflurane group was lower than that in propofol group after operation(P<0.01).Conclusions:The sevoflurane anesthesia do not increase the serum levels of ALT and AST and injure the liver in cirrhosis patients treated with partial hepatectomy,and the analgesic effect of which is good.

       

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