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    周庆, 刘倩. EV71感染手足口病患儿血清白细胞介素-37和白细胞介素-33水平检测[J]. 蚌埠医科大学学报, 2018, 43(1): 78-80. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.023
    引用本文: 周庆, 刘倩. EV71感染手足口病患儿血清白细胞介素-37和白细胞介素-33水平检测[J]. 蚌埠医科大学学报, 2018, 43(1): 78-80. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.023
    shu
    ZHOU Qing, LIU Qian. The serum levels of interleukin-37 and interleukin-33 in children with hand-foot-mouth disease caused by enterovirus 71 infection[J]. Journal of Bengbu Medical University, 2018, 43(1): 78-80. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.023
    Citation: ZHOU Qing, LIU Qian. The serum levels of interleukin-37 and interleukin-33 in children with hand-foot-mouth disease caused by enterovirus 71 infection[J]. Journal of Bengbu Medical University, 2018, 43(1): 78-80. DOI: 10.13898/j.cnki.issn.1000-2200.2018.01.023
    shu

    EV71感染手足口病患儿血清白细胞介素-37和白细胞介素-33水平检测

    The serum levels of interleukin-37 and interleukin-33 in children with hand-foot-mouth disease caused by enterovirus 71 infection

      摘要
    • 摘要: 目的：研究EV71感染手足口病（HFMD）患儿血清白细胞介素（IL）-37和IL-33水平并分析其意义。方法：收集180例确诊的EV71感染HFMD患儿（观察组）和100名健康体检儿童（对照组）外周血，采用全自动血球分析仪检测外周血中性粒细胞和单核细胞绝对值，采用ELISA法检测血清IL-37和IL-33水平，并分析其相关性。结果：观察组外周血中性粒细胞绝对值、单核细胞绝对值、血清IL-37水平和血清IL-33水平均显著高于对照组（P<0.01）；重症组EV71感染HFMD患儿外周血中性粒细胞绝对值、单核细胞绝对值、血清IL-37水显著平均高于轻症组（P<0.05~P<0.01）；观察组血清IL-37与IL-33水平呈正相关关系（P<0.05）；重症组血清IL-37水平与外周血单核细胞绝对值呈正相关关系（P<0.05）；重症组血清IL-33水平与外周血中性粒细胞绝对值呈正相关关系（P<0.05）。结论：EV71感染手足口病重症患儿IL-37、IL-33水平改变可能与手足口病发病及病情发展有关。

       

      Abstract: Objective:To detect the serum levels of interleukin(IL)-37 and IL-33 in children with hand-foot-mouth disease(HFMD) caused by enterovirus 71 infection,and analyze its clinical significance.Methods:The absolute values of peripheral blood neutrophils and monocytes,and serum levels of IL-37 and IL-37 in 180 children with HFMD infected by EV71(observation group) and 100 healthy children(control group) were detected using the automatic blood cell analyzer and ELISA,respectively,and the correlations were analyzed.Results:The absolute values of neutrophils and monocytes,and serum levels of IL-37 and IL-33 in observation group were significantly higher than those in control group(P<0.01).The absolute values of neutrophils and monocytes,and serum level of IL-37 in children with severe EV71 infection were higher than those in mild EV71 infection children(P<0.05 to P<0.01).The serum levels of IL-37 in observation group were positive correlation with the serum level of IL-33(P<0.05).In severe group,the serum level of IL-37 was positively correlated to the absolute value of monocytes(P<0.05),and the serum level of IL-33 was positively correlated to the absolute value of neutrophils(P<0.05).Conclusions:The changes of IL-37 and IL-33 levels in children with HFMD infected by EV71 may be related to the pathogenesis of HFMD.

       

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