平均血小板体积/血小板比值与系统性红斑狼疮活动性的相关性分析

Correlation analysis between mean platelet volume/platelet ratio and systemic lupus erythematosus activity

摘要: 目的：探讨平均血小板体积/血小板计数比值（MPR）与系统性红斑狼疮（SLE）临床指标的相关性。方法：选取36例SLE病人（SLE组），另选取40名年龄和性别相匹配的同期正常体检人员为对照组（HC组）。对平均血小板体积（MPV）、MPR与SLE病人疾病活动指数（SLEDAI）、红细胞沉降率（ESR）等SLE疾病活动指标行回顾性分析。结果：MPV和MPR在SLE组病人中均高于HC组（P<0.05和P<0.01）；ESR与MPV、MPR均呈正相关关系（P<0.01和P<0.05）。SLEDAI与MPR亦呈正相关关系（P<0.01），和MPV未见相关性（P>0.05）。结论：MPR可能是评估SLE疾病活动的良好指标。

Abstract: Objective:To investigate the correlation between mean platelet volume/platelet ratio(MPR) and systemic lupus erythematosus(SLE).Methods:Thirty-six SLE patients and 40 age-and gender-matched medical examiner were divided into the SLE group and control group,respectively.The MPV,MPR,SLE disease activity index(SLEDAI) and erythrocyte sedimentation rate(ESR) were retrospectively analyzed.Results:The levels of MPV and MPR in SLE group were higher than those in control group(P<0.05 and P<0.01).The ESR was positively correlated with MPV and MPR(P<0.01 and P<0.05).The MPR was positively correlated with SLEDAI(P<0.01),and the MPV was not obviously correlated with SLEDAI(P>0.05).Conclusions:MPR may be an useful index in estimating the SLE activity.