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    张海莲, 朱云, 张琦, 王增慧, 刘军权. 慢性胃炎CD4+T、CD8+T细胞及Foxp3的表达及意义[J]. 蚌埠医科大学学报, 2018, 43(9): 1147-1150,1153. DOI: 10.13898/j.cnki.issn.1000-2200.2018.09.008
    引用本文: 张海莲, 朱云, 张琦, 王增慧, 刘军权. 慢性胃炎CD4+T、CD8+T细胞及Foxp3的表达及意义[J]. 蚌埠医科大学学报, 2018, 43(9): 1147-1150,1153. DOI: 10.13898/j.cnki.issn.1000-2200.2018.09.008
    shu
    ZHANG Hai-lian, ZHU Yun, ZHANG Qi, WANG Zeng-hui, LIU Jun-quan. Expression and significance of CD4+T cells,CD8+T cells and Foxp3 in patients with chronic gastritis[J]. Journal of Bengbu Medical University, 2018, 43(9): 1147-1150,1153. DOI: 10.13898/j.cnki.issn.1000-2200.2018.09.008
    Citation: ZHANG Hai-lian, ZHU Yun, ZHANG Qi, WANG Zeng-hui, LIU Jun-quan. Expression and significance of CD4+T cells,CD8+T cells and Foxp3 in patients with chronic gastritis[J]. Journal of Bengbu Medical University, 2018, 43(9): 1147-1150,1153. DOI: 10.13898/j.cnki.issn.1000-2200.2018.09.008
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    慢性胃炎CD4+T、CD8+T细胞及Foxp3的表达及意义

    Expression and significance of CD4+T cells,CD8+T cells and Foxp3 in patients with chronic gastritis

      摘要
    • 摘要: 目的：通过检测人慢性胃炎中CD4+T、CD8+T细胞及Foxp3的表达情况，探讨免疫细胞及分子在疾病进展过程中变化情况及对疾病发展的影响。方法：收集胃镜下钳取20例浅表性胃炎（其中Hp阳性10例，Hp阴性10例），20例萎缩性胃炎（其中Hp阳性10例，Hp阴性10例）标本。采用免疫组织化学方法检测CD4+T、CD8+T细胞及Foxp3的表达。结果：Hp阳性萎缩性胃炎胃黏膜中CD4+T细胞、CD8+T细胞、Foxp3的表达均高于Hp阴性萎缩性胃炎及Hp阳性浅表性胃炎胃黏膜中的表达（P<0.01）。Hp阳性胃炎（浅表+萎缩）胃黏膜中CD4+T细胞、CD8+T细胞、Foxp3的表达量均高于Hp阴性胃炎（浅表+萎缩）胃黏膜中的表达（P<0.01）。Hp阳性浅表性胃炎胃黏膜中CD4+T细胞的表达高于Hp阴性浅表性胃炎胃黏膜中的表达（P<0.01），Hp阳性浅表性胃炎胃黏膜组中CD8+T细胞和Foxp3的表达与Hp阴性浅表性胃炎胃黏膜中的表达差异均无统计学意义（P>0.05）。结论：Hp感染阳性胃炎胃黏膜中T淋巴细胞亚群CD4+T细胞、CD8+T细胞的浸润和Foxp3表达均高于Hp阴性胃炎，且Hp感染阳性胃炎胃黏膜中，萎缩性胃炎T淋巴细胞亚群及Foxp3表达均高于浅表性胃炎。

       

      Abstract: Objective:To detect the levels of CD4+T cells,CD8+T cells and Foxp3 expression in human chronic gastritis,and investigate the level changes of immune cells and molecule during the process of disease progression and its influences on the development of the disease.Methods:Twenty superficial gastritis samples(Hp positive in 10 cases and Hp negative in 10 cases),and 20 atrophic gastritis samples(Hp positive in 10 cases and Hp negative in 10 cases) were collected.The levels of CD4+T cells,CD8+T cells and Foxp3 expression were detected using immunohistochemistry.Results:The CD4+T cells,CD8+T cells and Foxp3 level in Hp positive atrophic gastritis samples were higher than those in Hp negative atrophic gastritis samples and Hp positive superficial gastritis samples(P<0.01).The CD4+T cells,CD8+T cells and Foxp3 level in Hp positive atrophic and superficial gastritis samples were higher than those in Hp negative atrophic and superficial gastritis samples(P<0.01).The CD4+T cells in Hp positive superficial gastritis samples was higher than that in Hp negative superficial gastritis samples(P<0.01).The differences of the CD8+T cells and Foxp3 level between Hp positive and negative superficial gastritis samples were not statistically significant(P>0.05).Conclusions:The invasion of CD4+T cells and CD8+T cells,and Foxp3 level in HP positive gastritis are higher than those in HP negative gastritis.The T lymphocyte subtype and Foxp3 expression level in Hp positive atrophic gastritis are higher those in Hp positive superficial gastritis.

       

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