Abstract:
Objective:To observe the serum level of 25 hydroxy vitamin D325-(OH)D
3 in children with cough variant asthma(CVA),and analyze its relationship with serum level of total immunoglobulin E(T IgE) associated with CVA.
Methods:The serum levels of 25-(OH)D
3 and T IgE in 40 cases with cough variant asthma(cough variant asthma group) and 42 healthy children(normal control group) were detected,and which was compared between two groups.
Results:The serum levels of 25-(OH)D
3 and T IgE in CVA group were significantly lower and higher those in normal control group,respectively(
P<0.01).The serum level of 25-(OH)D
3 in CVA group was negatively correlated with level of T IgE(
r=-0.937,
P<0.01).
Conclusions:Vitamin D deficiency is an important cause of CVA exacerbations in children,which may be related to the inhibitory effect of 25-(OH)D
3 on the T IgE.