Abstract: China has entered an aging society.Numerous age-related diseases and functional decline accompanying aging are seriously threatening people's health.However,our understanding of aging mechanisms is still in its infancy.Systemic disorders and cellular and molecular alterations affect each other,which makes the mechanism of aging extremely complicated.In this review,we will elaborate the current status of basic research on aging a tmolecular,cellular and system levels.We will further discuss the inherent connections between aging and age-related diseases,and propose potential intervention strategies.Therefore,we will explore the feasibility of strategic transformation from "treating different diseases according to different guidelines" to "treating different diseases with the same guidance",and advocate healthy lifestyle to control the occurrence and development of aging-related diseases.