中老年人群代谢综合征与脑白质病变发生的相关性

郭均涛; 陈乐; 尹泽钢; 周华东

doi:10.13898/j.cnki.issn.1000-2200.2018.10.023

中老年人群代谢综合征与脑白质病变发生的相关性

Study on the association between white matter lesions and metabolic syndrome in middle-aged and elderly

摘要

摘要: 目的：探讨中老年人群代谢综合征（Metabolic syndrome，MetS）与脑白质病变（white matter lesions，WML）发生的相关性。方法：临床纳入50岁以上MetS病人852例，经MRI影像检查诊断为WML。将病人按照WML部位分为脑室旁白质病变（PVWML）组和深部白质病变（DWML）组，并按照WML程度分为轻、中、重度。结果：MetS与非MetS病人相比，PVWML和DWML病变程度差异均有有统计学意义（P<0.01）。调整了年龄和性别后，logistic回归分析显示，MetS与PVWML和DWML的发生风险均有关，而MetS组分个数越多，PVWML和DWML的患病风险也越高（P<0.01）。结论：MetS可以增加WML的发生风险。

Abstract: Objective:To investigate the relationship between metabolic syndrome(MetS) and occurrence of white matter lesions(WML) in middle-aged and elderly.Methods:Eight hundred and fifty-two metabolic syndrome patients over 50 years old were diagnosed as WML using by MRI imaging.The patients were divided into the periventricular white matter lesions(PVWML) group and deep white matter lesions(DWML) according to the lesion site.According to the degree of WML,the patients were divided into the mild,moderate and severe degree.Results:The difference of the lesion degree in PVWML group and DWML group between Mets and nonMetS patients was statistically significant(P<0.01).After adjusting age and gender,the logistic regression analysis showed that MetS was associated with the risk of PVWML and DWML.The more the number of MetS components,the higher the risk of PVWML and DWML was(P<0.01).Conclusions:Metabolic syndrome can increase the risk of white matter lesions.

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