高级检索
    柳雯, 周兰, 杨小迪. 中医辨证维持疗法对晚期非小细胞肺癌生存质量及生存期的影响[J]. 蚌埠医科大学学报, 2019, 44(6): 712-716. DOI: 10.13898/j.cnki.issn.1000-2200.2019.06.004
    引用本文: 柳雯, 周兰, 杨小迪. 中医辨证维持疗法对晚期非小细胞肺癌生存质量及生存期的影响[J]. 蚌埠医科大学学报, 2019, 44(6): 712-716. DOI: 10.13898/j.cnki.issn.1000-2200.2019.06.004
    shu
    LIU Wen, ZHOU Lan, YANG XIAO-di. Influence of TCM dialectical maintenance therapy on the living quality and life span in advanced NSCLC patients[J]. Journal of Bengbu Medical University, 2019, 44(6): 712-716. DOI: 10.13898/j.cnki.issn.1000-2200.2019.06.004
    Citation: LIU Wen, ZHOU Lan, YANG XIAO-di. Influence of TCM dialectical maintenance therapy on the living quality and life span in advanced NSCLC patients[J]. Journal of Bengbu Medical University, 2019, 44(6): 712-716. DOI: 10.13898/j.cnki.issn.1000-2200.2019.06.004
    shu

    中医辨证维持疗法对晚期非小细胞肺癌生存质量及生存期的影响

    Influence of TCM dialectical maintenance therapy on the living quality and life span in advanced NSCLC patients

      摘要
    • 摘要:
      目的观察一线化疗后中医辨证维持疗法对晚期非小细胞肺癌（NSCLC）生存质量及生存期的影响。
      方法将125例经标准一线化疗后取得缓解或稳定的晚期NSCLC病人，随机分为观察组62例和对照组63例，对照组予西医常规对症治疗，观察组在对照组基础上加用规范化中医辨证治疗，2组均治疗至疾病进展或不耐受，比较2组病人生存质量评分、中医证候评分变化，比较2组无进展生存期、总生存期情况。
      结果试验结束剔除脱落病例，共纳入统计122例，其中观察组60例，对照组62例。治疗后，观察组卡氏评分和中医证候评分有效率较对照组均提高（P < 0.05和P < 0.01）；生理状况、功能状况、附加情况评分均明显提高（P < 0.01），社会或家庭状况、情感状况评分差异均无统计学意义（P>0.05）；观察组中位无进展生存期13.90个月，大于对照组的11.30个月（P < 0.05），观察组中位总生存期28.90个月，与对照组的16.90个月比较差异无统计学意义（P>0.05）。
      结论中医辨证维持疗法应用于晚期NSCLC病人，可改善中医临床症状，提高生存质量，延长无进展生存期。

       

      Abstract:
      ObjectiveTo observe the effects of Traditional Chinese Medicine(TCM) dialectical maintenance therapy on the living quality and life span in advanced non-small-cell lung cancer(NSCLC) patients after first-line chemotherapy.
      MethodsOne hundred and twenty-five mitigatory or stable advanced NSCLC patients after standard first-line chemotherapy were randomly divided into the observation group(62 cases) and control group(63 cases).The control group received conventional symptomatic treatment with western medicine, and the observation group was treated with TCM dialectical maintenance therapy based on the control group.Two groups were treated to disease progression or intolerance.The scores of survival quality and TCM symptoms, progression-free survival(PFS) and overall survival(OS) were compared between two groups.
      ResultsAt the end of the experiment, 60 cases in observation group and 62 cases in control group were investigated.Compared with the control group, the scores of TCM symptoms and KPS scores were significantly improved(P < 0.05 and P < 0.01), and the scores of physiological, functional and additional status were also significantly improved in observation group after treatment(P < 0.01).The differences of the scores of emotional, social or family status between two groups after treatment were not statistically significant(P>0.05).The median PFS in observation group(13.90 months) was greater than that in control group(11.30 months)(P < 0.05).The median OS in observation group and control group were 28.90 months and 16.90 months, respectively, and the difference of which was not statistically significant(P>0.05).
      ConclusionsThe TCM dialectical maintenance therapy in treating NSCLC can improve the clinical symptoms of TCM and quality of life, and prolong the PFS of patients.

       

      • HTML全文
      • 参考文献(15)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回