2型糖尿病病人血清维生素D含量与甲状腺功能相关性研究

吴晨辰; 孙卫华; 张亚迪; 时照明; 张晓梅

doi:10.13898/j.cnki.issn.1000-2200.2019.06.014

2型糖尿病病人血清维生素D含量与甲状腺功能相关性研究

Correlation between the serum level of vitamin D and thyroid function in type 2 diabetes mellitus patients

摘要

摘要:
目的探讨2型糖尿病（T2DM）病人血清维生素D与甲状腺功能及临床指标间的相关性。
方法选择T2DM病人151例，根据血清25羟维生素D25（OH）D含量分为≥ 30 ng/mL正常组，20~ < 30 ng/mL不足组，10~ < 20 ng/mL缺乏组， < 10 ng/mL严重缺乏组，比较血清25（OH）D含量与各临床指标以及甲状腺功能之间的关系。
结果在T2DM人群中血清维生素D不足比例为89.40%，4组病人血清25（OH）D含量与游离三碘甲状腺原氨酸（FT3）、促甲状腺激素（TSH）、甲状腺球蛋白抗体（TGAb）和甲状腺微粒体抗体（TMAb）差异均有统计学意义（P < 0.05~P < 0.01）。logistic回归分析显示，T2DM病人血清25（OH）D含量与TSH呈负相关关系（P < 0.05）。
结论T2DM病人体内血清维生素D缺乏和TSH之间呈负相关，对于T2DM病人应考虑及时补充维生素D，并注意监测其甲状腺功能水平。

Abstract:
ObjectiveTo explore the correlation between the serum level of vitamin D and thyroid function, clinical indicators in type 2 diabetes mellitus(T2DM) patients.
MethodsAccording to the serum level of 25 hydroxyvitamin25(OH)D, 151 patients with T2DM were divided into the normal group(≥ 30 ng/mL), insufficient group(20~30 ng/mL), deficient group(10~20 ng/mL) and severely deficient group(< 10 ng/mL).The relationship between the serum level of 25(OH)D and clinical indicators, thyroid function was compared.
ResultsThe proportion of patients with serum vitamin D deficiency was 89.40% among the T2DM patients.The differences of the correlations of serum levels of vitamin D with FT3, TSH and TGAb and TMAb among four groups were statistically significant(P < 0.05).Logistic regression analyses indicated that the serum level of vitamin D was negatively correlated with TSH in T2DM patients.
ConclusionsThe serum vitamin D deficiency is negatively correlated with TSH in patients with T2DM.Supplementing vitamin D and monitoring thyroid function should be considered in patients with T2DM.

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