磷酸铝凝胶联合康复新液保留灌肠预防宫颈癌放疗后放射性肠炎的临床研究

臧春宝; 吴爱林; 王慧妍; 徐成胜; 尹琍; 柯学; 倪进; 刘珂; 刘云琴

doi:10.13898/j.cnki.issn.1000-2200.2019.08.007

磷酸铝凝胶联合康复新液保留灌肠预防宫颈癌放疗后放射性肠炎的临床研究

Clinical study of Aluminum Phosphate Gel Combined with Kangfuxin Liquid retention-enema in preventing radioactive enteritis after radiotherapy for cervical cancer

摘要

摘要:
目的探讨磷酸铝凝胶联合康复新液保留灌肠对宫颈癌放疗后放射性肠炎的预防作用。
方法选择2014-2015年收治的宫颈癌病人100例，将病人按随机数表法分为2组，各50例。对照组单纯放疗，治疗组放疗同时予保留灌肠磷酸铝凝胶和康复新液治疗，放疗后进行肠镜及磁共振检查，2组病例随访1年，对比2组病人放射性肠炎的发生时间、放射性肠炎的严重程度、发生率、维也纳直肠镜评分、磁共振直肠壁厚度及药物不良反应。
结果治疗组急性放射性肠炎的发生率明显低于对照组（P < 0.01）。治疗组急性放射性肠炎的平均发生时间明显长于对照组（P < 0.01）；对照组急慢性放射性肠炎的发生率明显高于治疗组（P < 0.01）。相对于治疗组维也纳直肠镜评分1~5分病例较对照组多，其中0~2分治疗组得分高于对照组（P < 0.05），3~5分治疗组得分低于对照组（P < 0.05）。对照组直肠壁厚度明显厚于治疗组（P < 0.01）。
结论磷酸铝凝胶联合康复新液保留观察能明显推迟宫颈癌放疗后放射性肠炎的发生时间，降低其发生率及严重程度，不增加不良反应，对宫颈癌放疗所致放射性肠炎有预防作用。

Abstract:
ObjectiveTo investigate the preventive effect of Aluminium Phosphate Gel combined with Kangfuxin Liquid retention enema on radiation enteritis after radiotherapy for cervical cancer.
Methods100 cases of cervical cancer in our department from January 2014 to December 2015 were analyzed.The patients were divided into two groups according to random number table.The control group(n=50) was treated with radiotherapy alone, while the treatment group(n=50) was treated with retention enema Aluminium Phosphate Gel and Kangfuxin Liquid.After radiotherapy, colonoscopy and magnetic resonance imaging were performed.The two groups were followed up for one year.The occurrence time of radiation enteritis, the severity of radiation enteritis, and the incidence of radiation enteritis in two groups were compared with those of Vienna rectal speculum.MR imaging of rectal wall thickness and drug toxicity and side effects.
ResultsCompared with the control group, the occurrence time of radiation enteritis in the treatment group was significantly delayed; the incidence of radiation enteritis in the treatment group was significantly reduced from grade 1 to 4;the Vienna rectoscopy score in the treatment group was significantly reduced; the thickness of rectal wall in the treatment group was reduced, and the toxicity and side effects in the treatment group were not significantly increased.
ConclusionsThe observation of Aluminium Phosphate Gel combined with Kangfuxin Liquid can significantly delay the occurrence time of radiation enteritis after radiotherapy, reduce the incidence and severity of cervical enteritis without increasing toxic and side effects, and prevent the occurrence of radiation enteritis caused by radiotherapy for cervical cancer.

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