谢静, 叶明, 刘东亮, 许娟娟, 许力, 刘晓林, 孙中武. 氯吡格雷联合拜阿司匹林对老年急性脑梗死病人疗效及对细胞炎症因子、凝血功能的影响[J]. 蚌埠医学院学报, 2019, 44(8): 1009-1011. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.008
    引用本文: 谢静, 叶明, 刘东亮, 许娟娟, 许力, 刘晓林, 孙中武. 氯吡格雷联合拜阿司匹林对老年急性脑梗死病人疗效及对细胞炎症因子、凝血功能的影响[J]. 蚌埠医学院学报, 2019, 44(8): 1009-1011. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.008
    XIE Jing, YE Ming, LIU Dongliang, XU Juan-juan, XU Li, LIU Xiao-lin, SUN Zhong-wu. Effect of clopidogrel combined with aspirin on inflammatory cytokines and coagulation function in elderly patients with acute cerebral infarction[J]. Journal of Bengbu Medical College, 2019, 44(8): 1009-1011. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.008
    Citation: XIE Jing, YE Ming, LIU Dongliang, XU Juan-juan, XU Li, LIU Xiao-lin, SUN Zhong-wu. Effect of clopidogrel combined with aspirin on inflammatory cytokines and coagulation function in elderly patients with acute cerebral infarction[J]. Journal of Bengbu Medical College, 2019, 44(8): 1009-1011. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.008

    氯吡格雷联合拜阿司匹林对老年急性脑梗死病人疗效及对细胞炎症因子、凝血功能的影响

    Effect of clopidogrel combined with aspirin on inflammatory cytokines and coagulation function in elderly patients with acute cerebral infarction

    • 摘要:
      目的探讨氯吡格雷联合拜阿司匹林对老年急性脑梗死病人疗效及对细胞炎症因子、凝血功能的影响。
      方法将105例老年急性脑梗死病人随机分为2组,观察组(52例)采用氯吡格雷联合拜阿司匹林治疗,对照组(53例)采用拜阿司匹林治疗。观察2组疗效以及治疗前后炎症因子高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-33(IL-33)、凝血功能凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血因子ⅩⅢ(FⅩⅢ)的变化和差异。
      结果观察组有效率高于对照组(P < 0.05)。治疗后观察组血清Hs-CRP、TNF-α、IL-33均低于对照组(P < 0.05),血清PT、APTT均高于对照组(P < 0.05),FⅩⅢ低于对照组(P < 0.05)。
      结论氯吡格雷联合拜阿司匹林可提高急性脑梗死病人治疗疗效,降低炎症反应,改善凝血功能,效果优于单独拜阿司匹林。

       

      Abstract:
      ObjectiveTo investigate the effects of clopidogrel combined with aspirin on inflammatory cytokines and coagulation function in elderly patients with acute cerebral infarction.
      MethodsOne hundred and five elderly patients with acute cerebral infarction were randomly divided into the observation group(52 cases) and control group(53 cases).The observation group and control group were treated with clopidogrel combined with aspirin and aspirin, respectively.The curative effect and differences of inflammatory factorsincluding high sensitivity C-reactive protein(hs-CRP), tumor necrosis factor-alpha(TNF-alpha) and interleukin-33 (IL-33), thrombin function indictorsincluding prothrombin time(PT), activated partial thromboplastin time(APTT) and thrombin factor_Ⅲ (FⅩⅢ) between before and after treatment were observed in two groups.
      ResultsThe effective rate in observation group was higher than that in control group(P < 0.05).After treatment, the serum levels of Hs-CRP, TNF-a and IL-33 in observation group were lower than those in control group(P < 0.05), and the levels of PT and APTT in observation group were higher than those in control group(P < 0.05), and the level of F X Ⅲ in observation group was lower than that in control group(P < 0.05).
      ConclusionsThe clopidogrel combined with baiaspirin can improve the therapeutic effect of acute cerebral infarction, reduce the inflammation reaction, improve coagulation function, and the effect of which is better than that of baiaspirin alone.

       

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