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    赵文婷, 刘路然. 依达拉奉对重组组织纤溶酶原激活剂治疗急性脑梗死病人期间氧自由基的清除作用[J]. 蚌埠医科大学学报, 2019, 44(8): 1012-1014, 1019. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.009
    引用本文: 赵文婷, 刘路然. 依达拉奉对重组组织纤溶酶原激活剂治疗急性脑梗死病人期间氧自由基的清除作用[J]. 蚌埠医科大学学报, 2019, 44(8): 1012-1014, 1019. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.009
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    ZHAO Wen-ting, LIU Lu-ran. Scavenging effect of edaravone on oxygen free radical in acute cerebral infarction patients treated with recombinant tissue plasminogen activator[J]. Journal of Bengbu Medical University, 2019, 44(8): 1012-1014, 1019. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.009
    Citation: ZHAO Wen-ting, LIU Lu-ran. Scavenging effect of edaravone on oxygen free radical in acute cerebral infarction patients treated with recombinant tissue plasminogen activator[J]. Journal of Bengbu Medical University, 2019, 44(8): 1012-1014, 1019. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.009
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    依达拉奉对重组组织纤溶酶原激活剂治疗急性脑梗死病人期间氧自由基的清除作用

    Scavenging effect of edaravone on oxygen free radical in acute cerebral infarction patients treated with recombinant tissue plasminogen activator

      摘要
    • 摘要:
      目的观察依达拉奉治疗对重组组织纤溶酶原激活剂治疗急性脑梗死病人期间氧自由基的清除作用。
      方法选择60例急性脑梗死病人，随机分为观察组和对照组，每组30例，所有病人均接受脑梗死常规治疗和重组组织纤溶酶原激活剂治疗，在此基础上观察组加用依达拉奉治疗。分别于治疗前后测定病人血清中羟基自由基（OH）、一氧化氮（NO）、过氧化脂质（PLO）、过氧化物歧化酶（SOD）、晚期氧化蛋白产物（AOPP）及丙二醛（MDA）的含量，并采用日常生活能力缺损评分（ADL）评定病人日常生活能力，采用神经功能缺损评分（NIHSS）量表评定神经功能缺损情况。
      结果治疗前2组OH、NO、PLO、SOD、AOPP、MDA水平和ADL、NIHSS评分差异均无统计学意义（P>0.05）。治疗后，2组OH、NO及PLO水平均明显低于治疗前（P < 0.01），且观察组病人的血清OH、NO及PLO水平明显低于对照组（P < 0.01）。治疗后，2组病人血清中的SOD、AOPP及MDA水平均明显低于治疗前（P < 0.01），且观察组病人的血清SOD、AOPP及MDA水平明显低于对照组（P < 0.01）。治疗后2组病人的ADL评分均较治疗前明显增高（P < 0.01），且观察组的评分明显高于对照组（P < 0.01），而NIHSS评分均有降低（P < 0.01），且观察组的评分明显低于对照组（P < 0.01）。
      结论在重组组织纤溶酶原激活剂治疗急性脑梗死病人的同时加用依达拉奉更能够有效清除氧自由基含量，减少氧化应激损伤，改善病人日常生活能力。

       

      Abstract:
      ObjectiveTo observe the scavenging effects of edaravone on oxygen free radical in acute cerebral infarction patients treated with recombinant tissue plasminogen activator.
      MethodsSixty patients with acute cerebral infarction were randomly divided into the observation group and control group(30 cases each group).All patients were treated with routine treatment method of cerebral infarction combined with recombinant tissue plasminogen activator, and the observation group were additionally treated with edaravone.The serum levels of Hydroxyl radical(OH), nitric oxide(NO), lipid peroxide(PLO), peroxide dismutase(SOD), advanced oxidative protein product(AOPP) and malondialdehyde(MDA) in two groups were measured before and after treatment.The daily living ability and neurological deficit in two groups were evaluated using ADL and NIHSS.
      ResultsBefore treatment, the differences of the levels of OH, NO, PLO, SOD, AOPP, MDA, ADL and NIHSS scores between two groups were statistically significant before treatment(P>0.05).After treatment, the levels of OH, NO and PLO in two groups were significantly lower than those before treatment(P < 0.01), and the serum levels of OH, NO and PLO in observation group were significantly lower than those in control group(P < 0.01).After treatment, the serum levels of SOD, AOPP and MDA in two groups were significantly lower than those before treatment(P < 0.01), and the serum levels of SOD, AOPP and MOD in observation group were significantly lower than those in control group(P < 0.01).After treatment, the ADL scores in two groups significantly increased compared before treatment(P < 0.01), and the ADL score in observation group were significantly higher than that in control group(P < 0.01).After treatment, the NIHSS scores in two groups decreased compared before treatment(P < 0.01), and the NIHSS score in observation group were significantly lower than that in control group(P < 0.01).
      ConclusionsThe recombinant tissue plasminogen activator combined with edaravone in the treatment of acute cerebral infarction can effectively scavenge oxygen free radical, reduce oxidative stress injury, and improve daily living ability.

       

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