ObjectiveTo investigate the effects of olanzapine on the cognitive function of schizophrenic patients complicated with or without metabolic syndrome, and its influencing factors.

MethodsFifty schizophrenic patients complicated with metabolic syndrome and 50 schizophrenic patients without metabolic syndrome from March 2014 to March 2017 were divided into the observation group and control group, respectively.The cognitive functions in two groups were observed and assessed using RBANS.

ResultsThere was statistical significance in the time and dose of drug use between two groups(P < 0.01), the total score of PANSS and negative symptom score in observation group were significantly higher than those in control group(P < 0.05), and there was no statistical significance in the positive symptom score and general pathological score(P>0.05).The levels of GLU, SBP and DBP in observation group were significantly higher than those in control group(P < 0.05 to P < 0.01), and the level of HDL in observation group was significantly lower than that in control group(P < 0.01).The scores of immediate memory, attention and delayed memory, and its total score in observation group were significantly lower than those in control group(P < 0.05).There was no statistical significance in the scores of the level of TG, visual breadth and speech function between two groups(P>0.05).

ConclusionsCompared with schizophrenic patients complicated without metabolic syndrome, the cognitive function of schizophrenic patients complicated with metabolic syndrome is worse, and the increasing of blood glucose level may be involved in the mechanism of cognitive impairment.