许力, 许娟娟, 李玉玉, 谢静, 刘楚楚, 屈洪党, 钱伟东, 周华东. 血清白细胞介素-17与视神经脊髓炎谱系疾病的关系[J]. 蚌埠医学院学报, 2019, 44(8): 1035-1038. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.015
    引用本文: 许力, 许娟娟, 李玉玉, 谢静, 刘楚楚, 屈洪党, 钱伟东, 周华东. 血清白细胞介素-17与视神经脊髓炎谱系疾病的关系[J]. 蚌埠医学院学报, 2019, 44(8): 1035-1038. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.015
    XU Li, XU Juan-juan, LI Yu-yu, XIE Jing, LIU Chu-chu, QU Hong-dang, QIAN Wei-dong, ZHOU Hua-dong. Study on the relationship between the serum level of interleukin-17 and neuromyelitis spectrum diseases[J]. Journal of Bengbu Medical College, 2019, 44(8): 1035-1038. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.015
    Citation: XU Li, XU Juan-juan, LI Yu-yu, XIE Jing, LIU Chu-chu, QU Hong-dang, QIAN Wei-dong, ZHOU Hua-dong. Study on the relationship between the serum level of interleukin-17 and neuromyelitis spectrum diseases[J]. Journal of Bengbu Medical College, 2019, 44(8): 1035-1038. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.015

    血清白细胞介素-17与视神经脊髓炎谱系疾病的关系

    Study on the relationship between the serum level of interleukin-17 and neuromyelitis spectrum diseases

    • 摘要:
      目的研究视神经脊髓炎谱系疾病(NMOSD)血清中白细胞介素17(IL-17)在发病中的意义及其与疾病严重程度的相关性。
      方法酶联免疫吸附法检测36例NMOSD急性期病人(NMOSD组)与30名健康志愿者(HCs组)血清IL-17;对NMOSD组血清IL-17水平与扩展残疾状况评分(EDSS)、脊髓受累节段数、病灶是否增强及水通道蛋白4抗体(AQP4-Ab)滴度等临床指标的相关性进行分析。
      结果NMOSD组血清IL-17水平为(35.54±10.71),较HCs组(HCs)(27.03±7.09)明显升高(P<0.001)。NMOSD组血清IL-17水平与EDSS评分、脊髓受累节段数呈正相关(P<0.01),病灶有强化者血清IL-17水平较病灶无强化者明显升高(P<0.01),AQP4-Ab对血清IL-17水平无影响(P>0.05)。多元回归分析显示血清IL-17水平与EDSS评分、脊髓受累节段数存在正相关性(P<0.01和P<0.05)。
      结论IL-17可能参与了NMOSD的发病过程,与疾病严重程度相关,可以作为病情判断及疾病潜在进展的预测指标之一。

       

      Abstract:
      ObjectiveTo investigate the significance of serum the level of interleukin-17(IL-17) in the neuromyelitis optica Spectrum disorders(NMOSD), and its correlation with disease severity.
      MethodsThe serum concentrations of IL-17 in 36 patients with NMOSD(NMOSD group) and 30 healthy volunteers(HCs group) were measured using enzyme-linked immunosorbent assay(ELISA).The correlations between serum level of IL-17 and extended disability score(EDSS), number of spinal cord involved segments, enhancement of lesion and titer of aquaphosin 4 antibody(AQP4-Ab) were analyzed in NMOSD group.
      ResultsThe serum level of IL-17 in NMOSD group(35.54±10.71) was significantly higher than in HCs group(27.03±7.09)(P < 0.01).The serum level of IL-17 in NMOSD group was positive correlation with EDSS score and number of spinal cord involved segments(P < 0.01), the serum level of IL-17 in patients with enhancement of lesion significantly increased compared with patients without enhancement of lesion(P < 0.01), and there was not significant correlation between IL-17 level and antibody titers of AQP4-Ab(P>0.05).The results of multivariate regression analysis showed that the serum level of IL-17 were positively correlated with EDSS score and number of spinal cord lesion(P < 0.01 and P < 0.05).
      ConclusionsThe IL-17 may participate in the pathogenic process of NMOSD, and can be used as one of the predictors in judging disease and potential progression of disease.

       

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