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    赵宏. 幽门螺杆菌感染与脑梗死同型半胱氨酸水平的相关性研究[J]. 蚌埠医科大学学报, 2019, 44(8): 1077-1078, 1081. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.027
    引用本文: 赵宏. 幽门螺杆菌感染与脑梗死同型半胱氨酸水平的相关性研究[J]. 蚌埠医科大学学报, 2019, 44(8): 1077-1078, 1081. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.027
    shu
    ZHAO Hong. Study on the correlation between Helicobacter pylori infection and homocysteine level in cerebral infarction patients[J]. Journal of Bengbu Medical University, 2019, 44(8): 1077-1078, 1081. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.027
    Citation: ZHAO Hong. Study on the correlation between Helicobacter pylori infection and homocysteine level in cerebral infarction patients[J]. Journal of Bengbu Medical University, 2019, 44(8): 1077-1078, 1081. DOI: 10.13898/j.cnki.issn.1000-2200.2019.08.027
    shu

    幽门螺杆菌感染与脑梗死同型半胱氨酸水平的相关性研究

    Study on the correlation between Helicobacter pylori infection and homocysteine level in cerebral infarction patients

      摘要
    • 摘要:
      目的探讨脑梗死的常见高危因素与幽门螺杆菌感染（HP）的相关性。
      方法通过对脑梗死病人常见高危因素与幽门螺杆菌感染情况的回顾性分析，了解其与幽门螺杆菌感染的关系。
      结果脑梗死组HP-IgG抗体阳性率与非脑梗死组HP-IgG抗体阳性率比较差异无统计学意义（P>0.05）；脑梗死组HP-IgG阳性组Hcy水平明显高于HP-IgG阴性组水平（P＜0.01）。调整性别、年龄、糖尿病、高血压、吸烟、饮酒等因素后，HP-IgG阳性是高Hcy水平的独立影响因素（OR=5.968，95% CI：1.506~23.647，P＜0.05）。
      结论脑梗死病人幽门螺杆菌感染率与普通人群无明显差异；脑梗死合并HP感染病人，HP对其血脂水平无明显影响；但HP感染可能通过升高血清Hcy水平，增加脑梗死风险。

       

      Abstract:
      ObjectiveTo explore the correlation between common high-risk factors of cerebral infarction and Helicobacter pylori(HP) infection.
      MethodsThe common high-risk factors and HP infection in patients with cerebral infarction were retrospectively analyzed, and their relationship was studied.
      ResultsThe difference of the positive rate of HP-IgG antibody between cerebral infarction group and non-cerebral infarction group was not statistically significant(P>0.05).The homocys-zing level in HP-IgG positive group was higher than that in HP-IgG negative group(P < 0.05).After adjusting the factors of gender, age, diabetes, hypertension, smoking and alcohol consumption, the positive HP-IgG was the independent influencing factor of high level of homocys-zing(OR=5.968, 95% CI:1.506~23.647, P < 0.05).
      ConclusionsThere is no significant difference in HP infection rate between cerebral infarction patients and general population.The HP in cerebral infarction patients complicated with HP infection has no significant effect on blood lipid level.However, HP infection may increase the risk of cerebral infarction by increasing the serum level of homocys-zing.

       

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