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    刘发军, 薛礼, 陈鸿武, 张磊. 心率变异性联合NT-proBNP对心力衰竭病人再入院率的预测价值[J]. 蚌埠医科大学学报, 2019, 44(9): 1166-1169. DOI: 10.13898/j.cnki.issn.1000-2200.2019.09.007
    引用本文: 刘发军, 薛礼, 陈鸿武, 张磊. 心率变异性联合NT-proBNP对心力衰竭病人再入院率的预测价值[J]. 蚌埠医科大学学报, 2019, 44(9): 1166-1169. DOI: 10.13898/j.cnki.issn.1000-2200.2019.09.007
    shu
    LIU Fa-jun, XUE Li, CHEN Hong-wu, ZHANG Lei. Predictive value of NT-proBNP and heart rate variability in readmission rate of patients with chronic heart failure[J]. Journal of Bengbu Medical University, 2019, 44(9): 1166-1169. DOI: 10.13898/j.cnki.issn.1000-2200.2019.09.007
    Citation: LIU Fa-jun, XUE Li, CHEN Hong-wu, ZHANG Lei. Predictive value of NT-proBNP and heart rate variability in readmission rate of patients with chronic heart failure[J]. Journal of Bengbu Medical University, 2019, 44(9): 1166-1169. DOI: 10.13898/j.cnki.issn.1000-2200.2019.09.007
    shu

    心率变异性联合NT-proBNP对心力衰竭病人再入院率的预测价值

    Predictive value of NT-proBNP and heart rate variability in readmission rate of patients with chronic heart failure

      摘要
    • 摘要:
      目的探讨心率变异性（HRV）联合血浆N-末端B型利钠肽原（NT-proBNP）水平对慢性心力衰竭（CHF）病人再入院率的预测价值。
      方法选取179例CHF病人为研究对象，根据心功能分级分组，入院均检测NT-proBNP水平，住院期间均行24 h动态心电图监测，出院后1、3、6个月随访并收集再入院率，分析各组HRV各指标联合NT-proBNP水平对再入院率的预测价值。
      结果不同级别心功能病人NT-proBNP、SDNN、RMSSD、PNN50和HRV三角指数差异均有统计学意义（P < 0.01）。心功能Ⅲ级与Ⅳ级CHF病人的NT-proBNP及HRV指标均显著高于心功能Ⅱ级（P < 0.01），心功能Ⅳ级显著高于心功能Ⅲ级者（P < 0.01）。心功能Ⅱ、Ⅲ和Ⅳ级CHF病人出院后1、3、6个月再入院率随着时间增加明显升高（P < 0.01），出院后同一时间再入院率随着心功能级别上升而显著增加（P < 0.01）。
      结论HRV各项时域指标联合NT-proBNP水平均对CHF患者再入院率有一定的预测价值。

       

      Abstract:
      ObjectiveTo investigate the predictive value of NT-proBNP and heart rate variability(HRV) in readmission rate of patients with chronic heart failure(CHF).
      MethodsA total of 179 patients with CHF were grouped according to the cardiac functional grading.The levels of NT-proBNP and ambulatory electrocardiograph in all cases were detected, the readmission rates were recorded after 1, 3 and 6 months of discharge, and the predictive value of the HRV indexes combined with NT-proBNP level in readmission rate of each group were analyzed.
      ResultsThe differences of SDNN, RMSSD, PNN50 and HRV triangular index among patients with different cardiac functional grades were statistically significant(P < 0.01).The levels of NT-proBNP and HRV indexes in patients with grade Ⅲ and Ⅳ CHF were significantly higher than those in patients with grade Ⅱ CHF(P < 0.01), and which in patients with grade Ⅳ CHF was significantly higher than that in patients with grade Ⅲ CHF(P < 0.01).The readmission rate in patients with grades Ⅱ, Ⅲ, and Ⅳ CHF increased significantly with the time increasing after 1, 3 and 6 months of discharge(P < 0.01), and the readmission rate at the same time increased with the increasing of heart failure grade(P < 0.01).
      ConclusionsThe HRV indexes combined with NT-proBNP level have important value in predicting the readmission rate of patients with CHF.

       

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